D101
（±）-DOI 盐酸盐
≥98% (HPLC), solid, 5-HT2 serotonin receptor agonist
别名:
（±）-1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷 盐酸盐, （±）-2,5-二甲氧基-4-碘代苯丙胺 盐酸盐, （±）-DOI
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关于此项目
经验公式（希尔记法）:
C11H16INO2 · HCl
化学文摘社编号:
分子量:
357.62
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
（±）-DOI 盐酸盐, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
drug control
Home Office Schedule 1; regulated under CDSA - not available from Sigma-Aldrich Canada, kontrollierte Droge in Deutschland
color
white to off-white
solubility
H2O: 10 mg/mL, ethanol: 2 mg/mL
SMILES string
NC(C)CC1=CC(OC)=C(I)C=C1OC.Cl
InChI
1S/C11H16INO2.ClH/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2;/h5-7H,4,13H2,1-3H3;1H
InChI key
QVFDMWGKHUFODK-UHFFFAOYSA-N
Gene Information
human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)
Biochem/physiol Actions
（±）-DOI盐酸盐是一种强效和选择性的5-HT2血清素受体激动剂，可穿过血脑屏障，增加多巴胺的周转，用DOI治疗可对抗尼古丁诱导的运动和神经化学敏化的表达，但对尼古丁诱导的行为去抑制没有影响。它对DOI的反应提供了证据，证明这些受体在皮质中含量丰富，在海马和小脑中含量相对较低。
Legal Information
German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
R Gaggi et al.
General pharmacology, 28(4), 583-587 (1997-04-01)
1. The behavioral responses, as well as the biogenic amines and metabolite contents in discrete brain areas were determined in male rats subcutaneously treated with a 5-HT1A (8-OHDPAT) or 5-HT2A (DOI) agonist at doses (0.5-2 mg/kg) sufficient to produce the
DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum.
J Ichikawa et al.
Brain research, 698(1-2), 204-208 (1995-11-06)
The effects of (+-)-DOI (1-(2,5-dimethoxy-4-iodophenyl)-aminopropane) hydrochloride, a mixed 5-HT2A/2C receptor agonist, on the release of dopamine (DA) following D-amphetamine sulfate (AMP) or a DA D2 autoreceptor selective dose of (-)-apomorphine hydrochloride (APO), were investigated in rat striatum (STR) and nucleus
G J Marek et al.
The Journal of pharmacology and experimental therapeutics, 278(3), 1373-1382 (1996-09-01)
Correlations between 5-hydroxytryptamine (5-HT) receptor binding affinities and human hallucinogenic potency have suggested that 5-HT2 receptors mediate the hallucinogenic effects of lysergic acid diethylamide (LSD) and phenethylamine hallucinogens. Electrophysiological studies have suggested that a subpopulation of gamma-aminobutyric acid (GABA)ergic interneurons
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D101-500MG | 04061832081816 |
| D101-100MG | 04061833558324 |
| D101-10MG | 04061833558331 |
| D101-25MG | 04061832090184 |