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D1064

二氢红藻氨酸

Name: 二氢红藻氨酸
Brand: SIGMA

≥98% (HPLC), GLT-1 glutamate transporter inhibitor, powder

别名:

2-羧基-4-异丙基-3-吡咯烷乙酸

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₇NO₄

化学文摘社编号:

52497-36-6

分子量:

215.25

UNSPSC Code:

12352106

PubChem Substance ID:

24277981

NACRES:

NA.77

MDL number:

MFCD03412037

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

二氢红藻氨酸, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

H₂O: >10 mg/mL

storage temp.

2-8°C

SMILES string

CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O

InChI

1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

InChI key

JQPDCKOQOOQUSC-OOZYFLPDSA-N

Gene Information

human ... SLC1A1(6505), SLC1A2(6506), SLC1A3(6507)
rat ... Slc1a2(29482), Slc1a3(29483)

说明

Application

在星形胶质细胞和神经胶质细胞的谷氨酸摄取测试中，二氢红藻氨酸（dihydrokainic acid）已被用作谷氨酸转运蛋白（GLT-1）抑制剂。它可以用作外侧缰核（Lateral habenula，LHb）中的GLT-1抑制剂。

Biochem/physiol Actions

二氢红藻氨酸会促进神经元细胞死亡。它可调节焦虑和抑郁行为。

二氢海藻酸是GLT-1谷氨酸转运蛋白的选择性抑制剂。在较高浓度下，二氢海藻酸酯是AMPA /海藻酸酯谷氨酸受体的弱抑制剂。

二氢红藻氨酸是一种选择性 GLT-1 谷氨酸转运体抑制剂；高浓度 AMPA/红藻氨酸谷氨酸受体的弱抑制剂。

Features and Benefits

该化合物收录于《受体分类和信号转导》手册的兴奋性氨基酸转运体页面。想要浏览手册的其他页面，请单击此处。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Beta-lactam antibiotic reduces morphine analgesic tolerance in rats through GLT-1 transporter activation.

Scott M Rawls et al.

Drug and alcohol dependence, 107(2-3), 261-263 (2009-12-17)

Glutamate transporter subtype 1 (GLT-1) activation is a promising - and understudied - approach for managing aspects of morphine tolerance caused by increased glutamatergic transmission. Identification of beta-lactam antibiotics as pharmaceuticals which activate GLT-1 transporters prompted us to hypothesize that

Regulation of glutamate transport in developing rat oligodendrocytes.

Tara M DeSilva et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(24), 7898-7908 (2009-06-19)

Glutamate released from synaptic vesicles mediates excitatory neurotransmission by stimulating glutamate receptors. Glutamate transporters maintain low synaptic glutamate levels critical for this process, a role primarily attributed to astrocytes. Recently, vesicular release of glutamate from unmyelinated axons in the rat

Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1.

Julie V Berger et al.

Journal of neuroinflammation, 8, 33-33 (2011-04-15)

Neuroinflammation and nitroxidative stress are implicated in the pathophysiology of neuropathic pain. In view of both processes, microglial and astroglial activation in the spinal dorsal horn play a predominant role. The present study investigated the severity of neuropathic pain and

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全球贸易项目编号

货号	GTIN
D1064-10MG	04061833558492
D1064-50MG	04061832081830