D1069
地氯雷他定
≥98% (HPLC), histamine H1 receptor antagonist, powder
别名:
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex®
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关于此项目
经验公式（希尔记法）:
C19H19ClN2
化学文摘社编号:
分子量:
310.82
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
地氯雷他定, powder, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1
InChI
1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
InChI key
JAUOIFJMECXRGI-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269)
Application
Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.
Biochem/physiol Actions
A non-sedating H1-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.
Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.
Legal Information
Clarinex is a registered trademark of Schering Corp.
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存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
390.2 °F - Pensky-Martens closed cup
flash_point_c
199 °C - Pensky-Martens closed cup
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D1069-10MG | 04061833558515 |
| D1069-50MG | 04061833558522 |