产品名称
GW4869, ≥90% (NMR)
Quality Level
assay
≥90% (NMR)
form
powder
storage condition
desiccated, protect from light
color
light yellow to yellow
mp
>300 °C
solubility
DMSO: 0.2 mg/mL
originator
GlaxoSmithKline
storage temp.
2-8°C
SMILES string
Cl.Cl.O=C(Nc1ccc(cc1)C2=NCCN2)\C=C/c3ccc(\C=C/C(=O)Nc4ccc(cc4)C5=NCCN5)cc3
InChI
1S/C30H28N6O2.2ClH/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;;/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*1H/b15-5-,16-6-;;
InChI key
NSFKAZDTKIKLKT-LOLTXFFGSA-N
General description
GW4869是一种常用的抑制外泌体生成的药物。它阻止神经酰胺介导的多泡体(MVBs)向内出芽和成熟外泌体从MVBs释放。GW4869对表达磷脂酰丝氨酸的骨髓瘤细胞具有细胞毒性。它通过浆细胞样树突状细胞(pDCs)而抑制干扰素(干扰素)-α的分泌。
Application
GW4869已可用于:
- 作为中性鞘磷脂酶和外泌体生物发生的抑制剂
- 分析三氧化二砷(ATO)治疗肝癌HCCLM3细胞对神经酰胺生成的影响
- 检测p75神经营养素受体(p75NTR)和原肌球蛋白受体激酶A (TrkA)-偶联通路对神经生长因子(NGF)诱导的大鼠热超敏的影响
Biochem/physiol Actions
N-SMase(中性鞘磷脂酶)的一种细胞渗透性、强效、特异性、非竞争性抑制剂
Features and Benefits
该化合物由 GlaxoSmithKline开发。要浏览其他药物开发的化合物和已批准药物/候选药物的列表,请单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Discover Bioactive Small Molecules for Lipid Signaling Research
E L Kavanagh et al.
Oncogenesis, 6(10), e388-e388 (2017-10-11)
Triple negative breast cancer (TNBC) is an aggressive subtype with relatively poor clinical outcomes and limited treatment options. Chemotherapy, while killing cancer cells, can result in the generation of highly chemoresistant therapeutic induced senescent (TIS) cells that potentially form stem
Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity
Dreux M, et al.
Cell host & microbe, 12(4), 558-570 (2012)
Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction
Essandoh K, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1852(11), 2362-2371 (2015)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D1692-25MG | 04061833560457 |
| D1692-5MG | 04061833560464 |