D1822
多西环素 一水合物
别名:
6-Deoxy-5-oxytetracycline monohydrate, Doxycycline
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关于此项目
经验公式（希尔记法）:
C22H24N2O8 · H2O
化学文摘社编号:
分子量:
462.45
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51284030
MDL number:
form
powder or crystals
Quality Level
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites
mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14
InChI
1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key
XQTWDDCIUJNLTR-CVHRZJFOSA-N
Gene Information
human ... MMP1(4312), MMP13(4322), MMP7(4316), MMP8(4317)
Application
- In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
- It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
- It has also been used as an antimicrobial agent.
Biochem/physiol Actions
Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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signalword
Warning
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2
法规信息
涉药品监管产品
此项目有
In vitro antimicrobial susceptibility testing of bacterial enteropathogens causing traveler's diarrhea in four geographic regions.
Gomi H, et al.
Antimicrobial Agents and Chemotherapy, 45, 212-216 (2001)
I Chopra et al.
Microbiology and molecular biology reviews : MMBR, 65(2), 232-60 (2001-05-31)
Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. They are inexpensive antibiotics, which have been used extensively in the prophlylaxis and therapy
Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro.
Li HT, et al.
The Biochemical Journal, 467, 507-515 (2015)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D1822-500MG | 04061833560853 |