D4010
2′-脱氧鸟苷5′-三磷酸 钠盐 水合物
≥96% (HPLC), synthetic (organic), powder
别名:
2′-脱氧-, 5′-三磷酸钠盐, 鸟苷, dGTP 钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C10H16N5O13P3 · xNa+ · yH2O
化学文摘社编号:
分子量:
507.18 (anhydrous free acid basis)
MDL number:
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
Assay:
≥96% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Storage temp.:
−20°C
产品名称
2′-脱氧鸟苷5′-三磷酸 钠盐 水合物, ≥96% (HPLC)
biological source
synthetic (organic)
Quality Level
assay
≥96% (HPLC)
form
powder
shipped in
dry ice
storage temp.
−20°C
Application
2′-脱氧鸟苷5′-三磷酸钠盐水合物已用于：
- 用作聚合酶链式反应 (PCR) 混合物中的一种成分，使用AM-毒素引物形成 PCR 产物
- 用作内标，提高毛细管电泳 (CE) 分析的分析性能，评估纯化工艺
- 用作体外酶活性测定中的推定底物，与Nudix水解酶 15 (NUDT15) 蛋白一起孵育，评估推定的 NUDT15 抑制剂
Biochem/physiol Actions
脱氧鸟苷5′-三磷酸(dGTP),一种嘌呤脱氧核糖核苷酸，是DNA聚合酶和逆转录酶的底物。 dGTP可用于研究各种核苷三磷酸酶(NTPase)和核糖核苷酸还原酶的分布、特异性和动力学。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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PloS one, 6(7), e22336-e22336 (2011-08-04)
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Yimon Aye et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(24), 9815-9820 (2011-06-02)
Human ribonucleotide reductases (hRNRs) catalyze the conversion of nucleotides to deoxynucleotides and are composed of α- and β-subunits that form active α(n)β(m) (n, m = 2 or 6) complexes. α binds NDP substrates (CDP, UDP, ADP, and GDP, C site)
Si Min Zhang et al.
Cell chemical biology, 28(12), 1693-1702 (2021-07-01)
Ganciclovir (GCV) is the first-line therapy against human cytomegalovirus (HCMV), a widespread infection that is particularly dangerous for immunodeficient individuals. Closely resembling deoxyguanosine triphosphate, the tri-phosphorylated metabolite of GCV (GCV-TP) is preferentially incorporated by the viral DNA polymerase, thereby terminating
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D4010-100MG | 04061833563847 |
| D4010-10MG | 04061833006856 |
| D4010-1G | 04061826690550 |