D4635
2′-脱氧胞苷 5′-三磷酸 二钠盐
≥95%
别名:
dCTP-Na2
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关于此项目
经验公式（希尔记法）:
C9H14N3Na2O13P3
化学文摘社编号:
分子量:
511.12
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥95%
Form:
powder
Storage temp.:
−20°C
Quality Level
assay
≥95%
form
powder
shipped in
dry ice
storage temp.
−20°C
SMILES string
[Na+].[Na+].NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)O2
InChI
1S/C9H16N3O13P3.2Na/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17;;/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17);;/q;2*+1/p-2/t5-,6+,8+;;/m0../s1
InChI key
ABWVCNMFYVEBIB-CDNBRZBRSA-L
General description
2′-脱氧胞苷5′-三磷酸（dCTP）通过从头途径或胞苷的多个磷酸化步骤合成。它被脱氨基为脱氧尿苷单磷酸（dUMP），后者可转化为脱氧胸苷三磷酸（dTTP）。
Application
2′-脱氧胞苷 5′-三磷酸二钠盐是用于 DNA 聚合酶驱动反应如聚合酶链反应、DNA 测序等分子生物学方法的三磷酸核苷之一。
2′-脱氧胞苷5′-三磷酸二钠盐已用于：
- 在用于扩增链格孢菌（AM）毒素DNA的聚合酶链反应混合物中
- 用于添加毛细管电泳（CE）分析的寡核苷酸样品
- 用作5′-单磷酸腺苷（AMP）荧光素酶测定的组分
Biochem/physiol Actions
2′-脱氧胞苷5′-三磷酸（dCTP）用于通过DNA聚合酶或逆转录酶合成DNA。dCTP是脱氧胞苷酸（dCMP）脱氨酶的变构调节剂。它用于核苷酸库研究，核苷酸选择性和酶特异性研究，例如通过Rev1（一种γ家族DNA聚合酶）优选地掺入dCTP。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Paola Ferraro et al.
Nucleic acids research, 38(6), e85-e85 (2009-12-17)
Eukaryotic cells contain a delicate balance of minute amounts of the four deoxyribonucleoside triphosphates (dNTPs), sufficient only for a few minutes of DNA replication. Both a deficiency and a surplus of a single dNTP may result in increased mutation rates
Inchul Yang et al.
Analytical biochemistry, 335(1), 150-161 (2004-11-03)
A novel approach for quantitation of DNA (oligonucleotides) with an unprecedented accuracy of approximately 1% is reported. Quantitation of DNA is commonly performed by measuring UV absorption or fluorescence from dyes intercalated into DNA. Both methods need accurate quantitation standards
Irene Lee et al.
Biochimica et biophysica acta, 1804(5), 1064-1080 (2009-09-08)
DNA is a remarkable macromolecule that functions primarily as the carrier of the genetic information of organisms ranging from viruses to bacteria to eukaryotes. The ability of DNA polymerases to efficiently and accurately replicate genetic material represents one of the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D4635-1G | 04061826690567 |
| D4635-25MG | 04061833006887 |
| D4635-100MG | 04061833565575 |
| D4635-10MG | 04061833006870 |