跳转至内容
Merck
CN

D5011

5′-脱氧-5′-腺苷

≥98% (HPLC), synthetic (organic), powder

别名:

甲硫腺苷, MTA

登录 查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式(希尔记法):
C11H15N5O3S
化学文摘社编号:
分子量:
297.33
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Beilstein/REAXYS Number:
42420
Assay:
≥98% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
Storage temp.:
−20°C
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助


产品名称

5′-脱氧-5′-腺苷,

biological source

synthetic (organic)

Quality Level

assay

≥98% (HPLC)

form

powder

solubility

DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23

InChI

1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

InChI key

WUUGFSXJNOTRMR-IOSLPCCCSA-N

Gene Information

Application

5′-脱氧-5′-(甲硫基)腺苷已被用作蛋白质甲基化抑制剂,可降低肝细胞癌(HCC)细胞中的E2F转录因子1(E2F1)蛋白丰度。这种成分还用于抑制组蛋白甲基化修饰,研究其在缺氧诱导因子1(Hif-1)核转运中的作用。

Biochem/physiol Actions

5′-脱氧-5′-(甲硫基)腺苷(甲硫腺苷)可用作底物来研究5′-甲硫腺苷磷酸化酶(MTAP)(EC2.4.2.28)的特异性和动力学,该酶是一个肿瘤抑制基因所表达的酶,其可支持S-腺苷甲硫氨酸(AdoMet)和蛋氨酸补救途径。


Still not finding the right product?

Explore all of our products under 5′-脱氧-5′-腺苷


存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库



Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells
Hong F, et al.
FEBS Open Bio, 8(3), 406-415 (2018)
Jiwoung Chung et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(29), 12089-12094 (2011-07-07)
Quorum sensing (QS) controls certain behaviors of bacteria in response to population density. In gram-negative bacteria, QS is often mediated by N-acyl-L-homoserine lactones (acyl-HSLs). Because QS influences the virulence of many pathogenic bacteria, synthetic inhibitors of acyl-HSL synthases might be
Ivan Hemeon et al.
Analytical chemistry, 83(12), 4996-5004 (2011-05-07)
DNA (cytosine-5)-methyltransferases (DNMTs) catalyze the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the 5-position of cytosine residues and thereby silence transcription of regulated genes. DNMTs are important epigenetic targets. However, isolated DNMTs are weak catalysts and are difficult



全球贸易项目编号

货号GTIN
D5011-100MG04061833585948
D5011-1G04061826690574
D5011-250MG04061833047941
D5011-25MG04061833585955