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关于此项目
经验公式(希尔记法):
C11H15N5O3S
化学文摘社编号:
分子量:
297.33
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Beilstein/REAXYS Number:
42420
Assay:
≥98% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
Storage temp.:
−20°C
产品名称
5′-脱氧-5′-腺苷,
biological source
synthetic (organic)
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
storage temp.
−20°C
SMILES string
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
InChI
1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
InChI key
WUUGFSXJNOTRMR-IOSLPCCCSA-N
Gene Information
human ... ADORA2B(136), ADORA3(140)
mouse ... Mtap(66902)
rat ... Adora1(29290), Adora2a(25369)
Application
5′-脱氧-5′-(甲硫基)腺苷已被用作蛋白质甲基化抑制剂,可降低肝细胞癌(HCC)细胞中的E2F转录因子1(E2F1)蛋白丰度。这种成分还用于抑制组蛋白甲基化修饰,研究其在缺氧诱导因子1(Hif-1)核转运中的作用。
Biochem/physiol Actions
5′-脱氧-5′-(甲硫基)腺苷(甲硫腺苷)可用作底物来研究5′-甲硫腺苷磷酸化酶(MTAP)(EC2.4.2.28)的特异性和动力学,该酶是一个肿瘤抑制基因所表达的酶,其可支持S-腺苷甲硫氨酸(AdoMet)和蛋氨酸补救途径。
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存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells
Hong F, et al.
FEBS Open Bio, 8(3), 406-415 (2018)
Jiwoung Chung et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(29), 12089-12094 (2011-07-07)
Quorum sensing (QS) controls certain behaviors of bacteria in response to population density. In gram-negative bacteria, QS is often mediated by N-acyl-L-homoserine lactones (acyl-HSLs). Because QS influences the virulence of many pathogenic bacteria, synthetic inhibitors of acyl-HSL synthases might be
Ivan Hemeon et al.
Analytical chemistry, 83(12), 4996-5004 (2011-05-07)
DNA (cytosine-5)-methyltransferases (DNMTs) catalyze the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the 5-position of cytosine residues and thereby silence transcription of regulated genes. DNMTs are important epigenetic targets. However, isolated DNMTs are weak catalysts and are difficult
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D5011-100MG | 04061833585948 |
| D5011-1G | 04061826690574 |
| D5011-250MG | 04061833047941 |
| D5011-25MG | 04061833585955 |