主要文件

查看所有文档

D5942

DAPT

Name: DAPT
Brand: SIGMA

≥98% (HPLC), solid, γ-secretase inhibitor

别名:

GSI-IX, LY-374973, N-[N-(3,5-二氟苯乙酰)-L-丙氨酰]-S-苯甘氨酸叔丁酯

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₃H₂₆F₂N₂O₄

化学文摘社编号:

208255-80-5

分子量:

432.46

UNSPSC Code:

12352200

PubChem Substance ID:

24893987

NACRES:

NA.77

MDL number:

MFCD04974585

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

DAPT, ≥98% (HPLC), solid

biological source

synthetic (organic)

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~18 mg/mL

originator

Eli Lilly

storage temp.

2-8°C

SMILES string

C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](C(=O)OC(C)(C)C)c2ccccc2

InChI

1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20+/m0/s1

InChI key

DWJXYEABWRJFSP-VBKZILBWSA-N

Gene Information

说明

Application

DAPT的应用实例：作为神经分化培养基(NDM)组分，启动皮层神经元模式，作为Notch信号传导抑制剂，研究它对斑马鱼毛细胞再生的影响，作为γ-分泌酶抑制剂抑制Notch通路，评估它对大鼠肺动脉平滑肌细胞(PASMC)增殖的影响

Biochem/physiol Actions

γ-分泌酶抑制剂，阻断Notch信号。

DAPT是一种γ-分泌酶抑制剂，间接抑制Notch，即一种γ-分泌酶底物。其他的γ-分泌酶底物包括LDL受体相关蛋白、E-cadherin和ErbB-4。DAPT作为γ-分泌酶的抑制剂，在 β-淀粉样蛋白的形成研究中可能具有重要的应用价值。DAPT在自身免疫性和淋巴增生性疾病的研究中，如阿尔卑斯和红斑狼疮(SLE)，以及在癌细胞生长、血管生成和人类诱导多能干细胞(hIPSC)分化中的作用已被证明可以抑制Notch信号。

Features and Benefits

该化合物是神经科学研究的特色产品。点击这里以发现更多的神经科学特色产品。在sigma.com/discover-bsm 上了解有关生物活性小分子在其他研究领域的更多信息。

该化合物由 Eli Lilly开发。要浏览其他药物开发的化合物和已批准药物/候选药物的列表，请单击此处。

Still not finding the right product?

Explore all of our products under DAPT

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

商品

癌症干细胞：癌症治疗的靶标

培养和表征CSC群体的癌症干细胞培养基、球状体培养板和癌症干细胞标志物。

DISCOVER Bioactive Small Molecules for Neuroscience

Cancer Stem Cells: Targets for Cancer Therapy

Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

Human Intestinal Enteroids Model MHC-II in the Gut Epithelium.

Jonathan E Wosen et al.

Frontiers in immunology, 10, 1970-1970 (2019-09-05)

The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, "mini-guts" derived from small intestinal crypt stem cells, and show that the

Safe and Efficacious Use of 1-Month Triple Therapy in Patients with Atrial Fibrillation and High Bleeding Risk Undergoing PCI.

Antonia Sambola et al.

Cardiovascular drugs and therapy, 33(4), 425-433 (2019-07-25)

The impact of short or prolonged use of triple therapy (TT) on outcomes in patients with atrial fibrillation (AF) and high risk of bleeding undergoing percutaneous coronary intervention (PCI) is unclear. We compared clinical outcomes according to the duration of

NOTCH Signaling via WNT Regulates the Proliferation of Alternative, CCR2-Independent Tumor-Associated Macrophages in Hepatocellular Carcinoma.

Yu-Chen Ye et al.

Cancer research, 79(16), 4160-4172 (2019-07-04)

Tumor-associated macrophages (TAM) play pivotal roles in tumor progression and metastasis, but the contribution and regulation of different macrophage populations remain unclear. Here we show that Notch signaling plays distinct roles in regulating different TAM subsets in hepatocellular carcinoma (HCC).

查看所有相关文献

全球贸易项目编号

货号	GTIN
D5942-25MG	04061833587089
D5942-5MG	04061833587096