D6035
达舒平 磷酸盐
别名:
双异丙吡胺
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关于此项目
线性分子式:
C21H29N3O · H3PO4
化学文摘社编号:
分子量:
437.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
244-756-1
MDL number:
Form:
solid
Quality level:
Quality Level
form
solid
SMILES string
OP(O)(O)=O.CC(C)N(CCC(C(N)=O)(c1ccccc1)c2ccccn2)C(C)C
InChI
1S/C21H29N3O.H3O4P/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19;1-5(2,3)4/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);(H3,1,2,3,4)
InChI key
CGDDQFMPGMYYQP-UHFFFAOYSA-N
Gene Information
Application
Disopyramide phosphate salt has been used as an internal standard for plasma sample analysis by mass spectrometry. It might be used as a test compound in a teratogenicity study.
Biochem/physiol Actions
Disopyramide is found to stabilize the cell membrane by altering the action potential. It might act as an antiarrhythmic agent.
IA 类抗心律失常药；钠通道阻断剂
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
0
Drugs for Pregnant and Lactating Women, 252-338 (2009)
Aziza El Harchi et al.
Journal of molecular and cellular cardiology, 52(1), 185-195 (2011-10-13)
The Class Ia antiarrhythmic drug disopyramide (DISO) causes QT interval prolongation that is potentially dangerous in acquired Long QT Syndrome but beneficial in short QT syndrome, through inhibition of the hERG-encoded channels responsible for rapid delayed rectifier K(+) current (I(Kr)).
Shunichiro Sumi et al.
Pacing and clinical electrophysiology : PACE, 33(6), e53-e56 (2010-01-12)
The patient was a 57-year-old man with Brugada syndrome, who had been implanted with a implantable cardioverter defibrillator (ICD). The frequency of ventricular fibrillation (VF) started to increase about 4 years after ICD implantation, occurring, at worst, six times in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D6035-10G | 04061832574318 |
| D6035-1G | 04061826226070 |