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D6513

去氢胆甾醇

Name: 去氢胆甾醇
Brand: SIGMA

≥84% (GC), cholesterol synthesis intermediate, powder

别名:

24-去氢胆甾醇, 3β-羟基-5,24-胆甾二烯, 5,24-胆甾二烯-3β-ol

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关于此项目

经验公式（希尔记法）:

C₂₇H₄₄O

化学文摘社编号:

313-04-2

分子量:

384.64

NACRES:

NA.77

PubChem Substance ID:

24894033

UNSPSC Code:

12352200

EC Number:

206-236-2

MDL number:

MFCD00056432

Assay:

≥84% (GC)

Form:

powder

Quality level:

200

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属性

产品名称

去氢胆甾醇, ≥84% (GC)

Quality Level

200

assay

≥84% (GC)

form

powder

storage temp.

−20°C

SMILES string

[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC=C(C)C

InChI

1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key

AVSXSVCZWQODGV-DPAQBDIFSA-N

说明

General description

链甾醇是胆固醇合成中C27甾醇的中间体。它可能与阿尔茨海默病′(AD)的发病机制有关。

Application

链甾醇已被用作估计胆固醇和植物甾醇浓度的标准品。此外，也可用于抑制尼日尔素诱导的固醇调节元件结合蛋白2 (SREBP2)的成熟。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

胆固醇生物合成

胆固醇的生物合成通常发生在肝细胞的内质网中，并以乙酰辅酶A开始，乙酰辅酶A主要来源于线粒体中的氧化反应。乙酰辅酶A和乙酰乙酰辅酶A由HMG-辅酶A合成酶转化为3-羟基-3-甲基戊二酰辅酶A（HMG-辅酶A）。

Cholesterol Biosynthesis

Cholesterol biosynthesis starts in the hepatic endoplasmic reticulum with acetyl-CoA, yielding 3-hydroxy-3-methylglutaryl-CoA via HMG-CoA synthase.

Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice.

Tim Vanmierlo et al.

Plant foods for human nutrition (Dordrecht, Netherlands), 66(2), 149-156 (2011-03-25)

Plant sterols such as sitosterol and campesterol are frequently applied as functional food in the prevention of atherosclerosis. Recently, it became clear that plasma derived plant sterols accumulate in murine brains. We questioned whether plant sterols in the brain are

Alzheimer's disease: brain desmosterol levels.

Thomas Wisniewski et al.

Journal of Alzheimer's disease : JAD, 33(3), 881-888 (2012-10-09)

Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It has become of particular interest in the pathogenesis of Alzheimer's disease (AD) because of the report that the activity of

Analysis of bioactive oxysterols in newborn mouse brain by LC/MS.

Anna Meljon et al.

Journal of lipid research, 53(11), 2469-2483 (2012-08-15)

Unesterified cholesterol is a major component of plasma membranes. In the brain of the adult, it is mostly found in myelin sheaths, where it plays a major architectural role. In the newborn mouse, little myelination of neurons has occurred, and

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全球贸易项目编号

货号	GTIN
D6513-10MG	04061833587737
D6513-5MG	04061833587744