D8040
反式 -U-50488 甲磺酸盐
别名:
反 -(±)-3,4-二氯-N-甲基-N- [2-（1-吡咯烷基）环己基] 苯乙酰胺 甲磺酸盐, U-50488H
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关于此项目
经验公式（希尔记法）:
C19H26Cl2N2O · CH4O3S
分子量:
465.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Form:
powder
Quality level:
form
powder
Quality Level
solubility
H2O: 50 mg/mL
storage temp.
2-8°C
SMILES string
CS(O)(=O)=O.CN([C@@H]1CCCC[C@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3
InChI
1S/C19H26Cl2N2O.CH4O3S/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;1-5(2,3)4/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H3,(H,2,3,4)/t17-,18-;/m1./s1
InChI key
OJPHNZCUXUUVKU-JAXOOIEVSA-N
Gene Information
human ... OPRK1(4986)
Application
(±)-反式-U-50488 甲磺酸盐已被用作 κ -阿片受体的对照激动剂。
Biochem/physiol Actions
选择性 κ-已知阿片受体激动剂 (±)-反式-U-50488 甲磺酸盐可诱导利尿。研究发现 U-50488H 与其联合给药时可预防吗啡耐受。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain
Basile AS, et al.
Journal of Pharmacology and Experimental Therapeutics, 321(3), 1208-1225 (2007)
X C Yu et al.
Journal of molecular and cellular cardiology, 31(10), 1809-1819 (1999-10-20)
During myocardial ischaemia the beta-adrenoceptor is activated, which contributes, at least partly, to cardiac arrhythmias via inducing [Ca2+]i oscillations. Since beta-adrenoceptor is negatively modulated by the kappa-opioid receptor in the heart, the present study attempted to determine if kappa-opioid receptor
Pharmacology and Therapeutics in the New Millennium, 462-462 (2001)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D8040-100MG | 04061833589151 |
| D8040-10MG | 04061832862095 |
| D8040-50MG | 04061832862101 |