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关于此项目
经验公式(希尔记法):
C17H25ClN2O3 · HCl
化学文摘社编号:
分子量:
377.31
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
S-(−)-Eticlopride 盐酸盐, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]27/D −7.2°, c = 0.3 in methanol(lit.)
storage condition
desiccated
color
off-white
solubility
H2O: soluble >10 mg/mL, ethanol: soluble 2.6 mg/mL, 0.1 M HCl: soluble 7 mg/mL
SMILES string
Cl.CCN1CCC[C@H]1CNC(=O)c2c(O)c(CC)cc(Cl)c2OC
InChI
1S/C17H25ClN2O3.ClH/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2;/h9,12,21H,4-8,10H2,1-3H3,(H,19,22);1H/t12-;/m0./s1
InChI key
HFJFXXDHVWLIKX-YDALLXLXSA-N
Gene Information
human ... DRD2(1813)
Application
S-(-)-盐酸依替必利已用于星形胶质细胞-神经元共培养 和官能性磁共振成像 (fMRI) 实验。
Biochem/physiol Actions
强效和选择性 D2 多巴胺受体拮抗剂。依替必利对 DAD2 受体的特异性高于匹莫齐特或氟哌啶醇。编码D2多巴胺受体(DRD2)的基因与包括帕金森病在内的多种疾病、精神分裂症和酒精中毒易感性有关。
Preparation Note
溶液可在 4° C下储存数天
Legal Information
经 Astra AB 许可生产和销售。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ciliary neurotrophic factor mediates dopamine D2 receptor-induced CNS neurogenesis in adult mice
Yang P, et al.
The Journal of Neuroscience, 28(9), 2231-2241 (2008)
Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23
Eubanks J H, et al.
Genomics, 14(4), 1010-1018 (1992)
Saurav Shome et al.
PloS one, 6(9), e25215-e25215 (2011-09-29)
Cutaneous wound healing is a normal physiological process and comprises different phases. Among these phases, angiogenesis or new blood vessel formation in wound tissue plays an important role. Skin is richly supplied by sympathetic nerves and evidences indicate the significant
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E101-100MG | 04061832090597 |
| E101-25MG | 04061832090603 |
| 330116-50G | 04061826725863 |