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E114

EHNA 盐酸盐

Name: EHNA 盐酸盐
Brand: SIGMA

≥98% (HPLC), powder, adenosine deaminase inhibitor

别名:

赤-9-氨基-& # 946;-己基-& # 945;-甲基-9H-嘌呤-9-乙醇盐酸盐, 赤-9-（2-羟基-3-壬基）腺嘌呤盐酸盐

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关于此项目

经验公式（希尔记法）:

C₁₄H₂₃N₅O · HCl

化学文摘社编号:

58337-38-5

分子量:

313.83

UNSPSC Code:

12352200

PubChem Substance ID:

24277713

NACRES:

NA.77

MDL number:

MFCD00151066

Assay:

≥98% (HPLC)

Quality level:

100

Storage condition:

desiccated

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属性

产品名称

EHNA 盐酸盐, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

storage condition

desiccated

solubility

DMSO: >10 mg/mL, H₂O: >10 mg/mL

SMILES string

Cl[H].CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12

InChI

1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m0./s1

InChI key

VVDXNJRUNJMYOZ-VZXYPILPSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)

说明

General description

EHNA是一种腺苷脱氨酶抑制剂。具有抗肿瘤作用。

Application

EHNA盐酸盐用于处于微外植体培养基，以检查负责自噬体在轴突中运动的方向和动作。此外，它还用于核苷补充，以抑制脱氧腺苷被酶腺苷酸脱氨酶分解。

Biochem/physiol Actions

腺苷脱氨酶抑制剂。

Features and Benefits

该化合物是受体分类及信号转导手册上磷酸二酯酶页面上的特色化合物。想要浏览手册的其他页面，请单击此处。

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma

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Cellular Physiology and Biochemistry, 35(1), 51-60 (2015)

Adenosine deaminase 2 activity negatively correlates with age during childhood.

Sarah M Bowers et al.

Pediatric rheumatology online journal, 18(1), 54-54 (2020-07-12)

Human adenosine deaminase 2 (ADA2) is an extracellular enzyme that negatively regulates adenosine-mediated cell signaling by converting adenosine to inosine. Altered ADA2 enzyme activity has been associated with some viral infections and rheumatic diseases. The potential utility of ADA2 as

Genetic Variability in Adenosine Deaminase-Like Contributes to Variation in Alcohol Preference in Mice.

Heidi M B Lesscher et al.

Alcoholism, clinical and experimental research, 41(7), 1271-1279 (2017-04-28)

A substantial part of the risk for alcohol use disorder is determined by genetic factors. We previously used chromosome substitution (CSS) mice, to identify a quantitative trait loci (QTL) for alcohol preference on mouse chromosome 2. The aim of this

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全球贸易项目编号

货号	GTIN
E114-25MG	04061833601402
E114-100MG	04061832947488