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E1657

EHT 1864

Name: EHT 1864
Brand: SIGMA

≥98% (HPLC), Rac function inhibitor, powder

别名:

5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride

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关于此项目

经验公式（希尔记法）:

C₂₅H₂₇F₃N₂O₄S · 2HCl

化学文摘社编号:

754240-09-0

分子量:

581.47

UNSPSC Code:

12352200

PubChem Substance ID:

329799014

NACRES:

NA.77

MDL number:

MFCD11114384

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

EHT 1864, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

Cl.Cl.FC(F)(F)c1ccc2c(SCCCCCOC3=COC(CN4CCOCC4)=CC3=O)ccnc2c1

InChI

1S/C25H27F3N2O4S.2ClH/c26-25(27,28)18-4-5-20-21(14-18)29-7-6-24(20)35-13-3-1-2-10-33-23-17-34-19(15-22(23)31)16-30-8-11-32-12-9-30;;/h4-7,14-15,17H,1-3,8-13,16H2;2*1H

InChI key

LSECOAJFCKFQJG-UHFFFAOYSA-N

说明

Application

EHT 1864 has been used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity.

Biochem/physiol Actions

EHT 1864 induces dissociation of bound nucleotides. EHT 1864 induced inhibition of Rac prevents its association with downstream effectors. It is known to prevent estrogen-induced tumor cell proliferation in breast cancer.

EHT 1864 inhibits Rac function.

EHT 1864 inhibits Rac function. It prevents Aβ40 and Aβ42 production in vitro without direct inhibition of g-secretase.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

EHT 1864 compound sold under license from ExonHit Therapeutics S.A. (www.exonhit.com)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

An integrated imaging approach to the study of oxidative stress generation by mitochondrial dysfunction in living cells.

Wan-Yun Cheng et al.

Environmental health perspectives, 118(7), 902-908 (2010-04-24)

The mechanisms of action of many environmental agents commonly involve oxidative stress resulting from mitochondrial dysfunction. Zinc is a common environmental metallic contaminant that has been implicated in a variety of oxidant-dependent toxicological responses. Unlike ions of other transition metals

Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts

Nethe M, et al.

Journal of Cell Science, jcs-100925 (2012)

Handbook of Cell Signaling, 2851-2851 (2009)

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全球贸易项目编号

货号	GTIN
E1657-10MG	04061832981505