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E5406

爱普杷嗪 盐酸盐

≥98% (HPLC), butyrylcholinesterase inhibitor, powder

别名:

10-(2-二乙氨基丙基)吩噻嗪, 10-[2-(二乙氨基)丙基]吩噻嗪 盐酸盐, 乙丙嗪, 二乙异丙嗪 盐酸盐

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关于此项目

经验公式（希尔记法）:
C19H24N2S · HCl
化学文摘社编号:
1094-08-2
分子量:
348.93
NACRES:
NA.77
PubChem Substance ID:
329799070
UNSPSC Code:
12352200
EC Number:
214-134-4
MDL number:
MFCD00012653
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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产品名称

爱普杷嗪 盐酸盐, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: >5 mg/mL at ~60 °C, clear

storage temp.

2-8°C

SMILES string

Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13

InChI

1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H

InChI key

VXPCQISYVPFYRK-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128)

General description

盐酸乙氧丙嗪具有抗胆碱能、抗组胺和抗肾上腺素能特性。

Biochem/physiol Actions

爱普杷嗪盐酸盐是一种丁酰胆碱酯酶的抑制剂；抗帕金森症药物
爱普杷嗪盐酸盐是一种丁酰胆碱酯酶的抑制剂；抗帕金森症药物。它可以减轻帕金森症的典型症状，即锥体外系副反应；还可以减轻小鼠的热痛觉过敏症状。

Features and Benefits

该化合物收录于受体分类和信号转导手册的《乙酰胆碱合成与代谢》页面。想要浏览手册的其他页面， 请单击此处。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
096M4753V
055M4711V
012M4707V
031M4744V
098K47142

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商品

乙酰胆碱合成及代谢

乙酰胆碱由胆碱乙酰转移酶从乙酰辅酶A和胆碱合成而来。用于生成乙酰胆碱的胆碱除了在肝脏中合成外，还来源于膳食。

Acetylcholine Synthesis and Metabolism

Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In addition to its synthesis in the liver, choline employed in acetylcholine production is derived from dietary sources.

Derek P Narendra et al.
PLoS biology, 8(1), e1000298-e1000298 (2010-02-04)
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes damaged mitochondria, however, is unknown. Here, we
Transition Metal Complexes of Ethopropazine: Synthesis and Characterization
Debbeti V, et al.
American Journal of Chemistry, 2(6), 294-298 (2012)
Katherine C M Chew et al.
PloS one, 6(5), e19720-e19720 (2011-06-01)
Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests that the enzyme is capable of catalyzing multiple forms
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全球贸易项目编号

货号GTIN
E5406-250MG04061833604304
E5406-50MG04061833604311