E8640
E-64d
powder, ≥98% (TLC)
别名:
(2S,3S)-反式-环氧琥珀酰基-L-亮氨酰氨基-3-甲基丁烷乙酯, EST
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关于此项目
经验公式（希尔记法）:
C17H30N2O5
化学文摘社编号:
分子量:
342.43
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
E-64d, protease inhibitor
biological source
synthetic (organic)
Quality Level
assay
≥98% (TLC)
form
powder
solubility
methanol: water (1:1): 5 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
InChI
1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
InChI key
SRVFFFJZQVENJC-IHRRRGAJSA-N
Gene Information
human ... CAPN1(823)
Application
E-64d已作为一种溶酶体抑制剂，被用于人类急性早幼粒细胞白血病NB4细胞 和Huh-7细胞中。它也已作为一种蛋白酶抑制剂，被用于游离钙生理酪氨酸溶液中，以用于对分离出的心脏样本的灌注。
Biochem/physiol Actions
E-64d是一种环氧琥珀酰肽，以及半胱氨酸蛋白酶组织蛋白酶B、钙蛋白酶1和2的抑制剂。 E-64d具有对组织蛋白酶B蛋白酶的抑制功能，可作为治疗颅脑外伤（TBI）和阿尔茨海默氏症′（AD）的潜在药物。它可抑制配子体表面抗原，从而减少恶性疟原虫卵囊的产生。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Shingo Nakamura et al.
Frontiers in plant science, 8, 1840-1840 (2017-11-23)
Wild barley (
Mebrahtom Gebrelibanos Hiben et al.
Journal of ethnopharmacology, 241, 111978-111978 (2019-06-01)
Maerua subcordata (Gilg) DeWolf is a medicinal and wild food plant growing mainly in east Africa. Especially its root tuber is widely used in traditional medicine to treat several infectious and chronic diseases but also in some toxicity implications like
Cathepsin B is a new drug target for traumatic brain injury therapeutics: evidence for E64d as a promising lead drug candidate
Hook G, et al.
Frontiers in Neurology, 6(9), 178-178 (2015)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E8640-1MG | 04061833608791 |
| E8640-250UG | 04061833608807 |