E8655
抗-E6AP小鼠单克隆抗体
clone E6AP-330, purified from hybridoma cell culture
别名:
Anti-E2F-6
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关于此项目
Conjugate:
unconjugated
Clone:
E6AP-330, monoclonal
Application:
ARR, ELISA (i), ICC, IP, WB
Citations:
31
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
E6AP-330, monoclonal
form
buffered aqueous solution
mol wt
antigen ~100 kDa
species reactivity
human, mouse, rat, monkey
technique(s)
immunocytochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 1-2 μg/mL using total cell extract from 293T cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... E2F6(1876)
mouse ... E2f6(50496)
rat ... E2f6(313978)
General description
E6AP 是一种 E3 泛素连接酶，由 UB3A 基因表达。UB3A 基因受到抑制或改变可能导致一种名为安格曼综合征的神经系统疾病。E6AP 与 E1 和 E2 酶相互作用，介导标记蛋白质的泛素化并使其酶解。E6AP 还与 HPV 感染细胞中存在的 E6 病毒蛋白结合。
抗 E6AP 单克隆抗体是研究 E6AP 及其在蛋白质酶解中的作用的有用工具。该抗体对大鼠、小鼠、人类和猴子的 E6AP 蛋白具有特异性。
抗 E6AP 单克隆抗体是研究 E6AP 及其在蛋白质酶解中的作用的有用工具。该抗体对大鼠、小鼠、人类和猴子的 E6AP 蛋白具有特异性。
Immunogen
人全长重组E6AP。
Application
抗-E6AP单克隆抗体适用于western blot（1-2 μg/mL使用来自293T细胞的总细胞提取物）、免疫细胞化学、免疫印迹、免疫沉淀、间接ELISA和微阵列。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Tiantian Wang et al.
Frontiers in cellular neuroscience, 11, 418-418 (2018-01-23)
The neurodevelopmental disorder Angelman syndrome (AS) is characterized by intellectual disability, motor dysfunction, distinct behavioral aspects, and epilepsy. AS is caused by a loss of the maternally expressed UBE3A gene, and many of the symptoms are recapitulated in a Ube3a
Yi Sun
Cancer biology & therapy, 2(6), 623-629 (2003-12-23)
E3 ubiquitin ligases are a large family of proteins that can be classified into three major structurally distinct types: N-end rule E3s, E3s containing the HECT (Homology to E6AP C-Terminus) domain, and E3s with the RING (Really Interesting New Gene)
Stuti Chhabra et al.
Biochimica et biophysica acta, 1864(10), 1545-1553 (2017-06-06)
Granulocyte colony-stimulating factor receptor (G-CSFR) plays a crucial role in regulating myeloid cell survival, proliferation, and neutrophilic granulocyte precursor cells maturation. Previously, we demonstrated that Fbw7α negatively regulates G-CSFR and its downstream signaling through ubiquitin-proteasome mediated degradation. However, whether additional
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E8655-200UL | 04061837896996 |