Anti-Endothelin B Receptor antibody produced in rabbit

synthetic peptide corresponding to the N-terminal extracellular domain of human endothelin B receptor, conjugated to KLH. The immunizing peptide has 79% homology with the mouse gene and 84% homology with the rat gene.

Anti-Endothelin B Receptor antibody produced in rabbit is suitable for the following applications:

• Immunocytochemistry at a concentration of 4-11μg/mL using human adrenal tissue
• Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 4-11μg/mL using human adrenal tissue
• Western blotting
• Immunofluorescence

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

EDNRB Endothelin receptor type B (ETB) is a protein encoded by the EDNRB gene in humans. It plays a pivotal role in oesophageal cancer and may act as a therapeutic target for this intractable malignancy. It has a novel role in oligodendroglioma proliferation and acts as a potential therapeutic alternative for oligodendrogliomas. Lower expression of ETB receptor responsiveness is associated with polycystic ovary syndrome (PCOS) and may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity.

Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.

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