F0503
5-氟-2′-脱氧尿嘧啶核苷
thymidylate synthase inhibitor
别名:
2′-脱氧-5-氟脲苷, FUDR, 氟脲苷
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关于此项目
经验公式（希尔记法）:
C9H11FN2O5
化学文摘社编号:
分子量:
246.19
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-072-5
Beilstein/REAXYS Number:
90221
MDL number:
UNSPSC Code:
12352208
biological source
synthetic (organic)
Quality Level
assay
≥99% (HPLC)
form
powder
mp
148 °C (lit.)
solubility
water: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
room temp
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O
InChI
1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key
ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Gene Information
human ... TYMS(7298)
mouse ... Tyms(22171)
General description
5-氟-2′-脱氧脲核苷，也称为氟脲苷，可在癌细胞中引起DNA介导的细胞毒性作用。氟脲苷可有效治疗肝癌 并且能够清除金黄色葡萄球菌（ Staphylococcus aureus）的毒性。氟脲苷与吉西他滨的二肽前药组合具有更强的细胞渗透性和抗增殖活性。氟脲苷能够有效治疗实体瘤和晚期癌症。
Application
5-氟-2′-脱氧脲核苷已被用作施旺（schwann）细胞增殖、胶质细胞增殖 和背根神经节培养物中非神经细胞的有丝分裂抑制剂。
Biochem/physiol Actions
一种抗肿瘤药物，是胸苷酸合成酶的有效抑制剂 通过低水平支原体感染，可使癌细胞培养物产生FUdR耐受性。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Elite Possik et al.
PLoS genetics, 10(4), e1004273-e1004273 (2014-04-26)
Dysregulation of AMPK signaling has been implicated in many human diseases, which emphasizes the importance of characterizing AMPK regulators. The tumor suppressor FLCN, responsible for the Birt-Hogg Dubé renal neoplasia syndrome (BHD), is an AMPK-binding partner but the genetic and
Cheng Shi et al.
Science (New York, N.Y.), 343(6170), 536-540 (2013-12-21)
Interactions between the germ line and the soma help optimize reproductive success. We discovered a phenomenon linking reproductive status to longevity: In both hermaphroditic and gonochoristic Caenorhabditis, mating leads to female shrinking and death, compressing postreproductive life span. Male sperm
Diana Andrea Fernandes de Abreu et al.
PLoS genetics, 10(3), e1004225-e1004225 (2014-03-29)
Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including development, reproduction, longevity and several specific stress responses.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F0503-100MG | 04061833611203 |
| F0503-1G | 04061833611227 |
| F0503-250MG | 04061833611234 |