F1180
抗-Flotillin 1 兔抗
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
抗-FLOT1, 抗-Reggie-2
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
18
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~48 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using human HEK-293K cells, western blot: 0.5-1 μg/mL using whole extract of mouse lung, western blot: 1-2 μg/mL using whole extract of rat lung
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FLOT1(10211)
mouse ... Flot1(14251)
rat ... Flot1(64665)
General description
Flotillin 1（FLOT1）也称为reggie-2，是一种雌激素反应性基因，位于人类染色体6p21.33。该基因编码整合膜蛋白和脂筏的成分。
Flotillin 是脂筏（lipid raft）相关蛋白，主要在脂肪组织、条纹肌肉组织和肺中表达。 它在多种细胞过程（如吞噬、胞吞、胰岛素信号传导和神经元再生）中起关键作用。抗flotillin 1 抗体可用于免疫印迹和免疫定位。兔抗flotillin 1抗体与大鼠、小鼠和人的flotillin 1 发生特异反应。
脂筏标记蛋白 1 编码与小窝相关的完整膜蛋白。小窝是内在细胞膜上的小区域，参与囊泡运输和信号转导。
Immunogen
对应于小鼠脂筏标记蛋白 1 的氨基酸残基 413-428 的合成肽，N-端添加了半胱氨酸，与 KLH 偶联。与大鼠中的相应序列相同，与人的相应序列相差 1 个氨基酸。
Application
兔抗-脂筏标记蛋白 1 抗体可用于免疫印迹分析。
抗脂筏标记蛋白 1 抗体可用于免疫荧光和蛋白质印迹。
Biochem/physiol Actions
Flotillin 1（(FLOT1）在胞吞作用中起一定作用。它也在生长因子信号传导中起作用，并激活丝裂原活化蛋白激酶信号传导。此外，它还参与吞噬作用以及肌动蛋白细胞骨架和膜转运的调节。该蛋白还与肿瘤进展有关，在许多癌症（包括乳腺癌）中表达。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F1180-200UL | 04061838031068 |