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F1293

非那雄胺

Name: 非那雄胺
Brand: SIGMA

≥98% (HPLC), Selective 5α-reductase inhibitor, powder

别名:

N-叔丁基-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺, MK-906, N-(2-甲基-2-丙基)-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺

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关于此项目

经验公式（希尔记法）:

C₂₃H₃₆N₂O₂

化学文摘社编号:

98319-26-7

分子量:

372.54

UNSPSC Code:

41116107

PubChem Substance ID:

24724479

NACRES:

NA.77

MDL number:

MFCD00869737

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

非那雄胺, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: soluble >20 mg/mL

storage temp.

room temp

SMILES string

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2

InChI

1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1

InChI key

DBEPLOCGEIEOCV-WSBQPABSSA-N

Gene Information

human ... HSD3B1(3283), SRD5A1(6715), SRD5A2(6716)
rat ... Hsd3b1(360348), Srd5a1(24950), Srd5a2(64677)

说明

Application

Finasteride has been used:

as a component of L-15 media to investigate the effects of finasteride exposure on brain, liver and testis tissues
in culture medium to treat tumor cells in vitro
as a positive control to treat benign prostatic hyperplasia (BPH)
to examine its effect on structural and molecular biology on the ventral prostate of senile mice

Biochem/physiol Actions

Finasteride can reduce serum and scalp dihydrotestosterone (DHT) by preventing the transformation of testosterone to DHT. It is usually used to manage benign prostate hyperplasia and pattern hair loss in male. Finasteride possesses androgen-distracting properties.

选择性 5α-还原酶抑制剂；抗雄激素。

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pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H360FD

pcodes

P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Finasteride adverse effects: An update

Carreno-Orellana N, et al.

Revista Brasileira de Farmacognosia, 144(12), 1584-1590 (2016)

Inhibitory effects of Ponciri Fructus on testosterone-induced benign prostatic hyperplasia in rats

Jeon W Y, et al.

BMC Complementary and Alternative Medicine, 17(1), 384-384 (2017)

Finasteride in the treatment of men with androgenetic alopecia

Kaufman K D, et al.

Journal of the American Academy of Dermatology, 39(4), 578-589 (1998)

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全球贸易项目编号

货号	GTIN
F1293-100MG	04061833611845