biological source
human
Quality Level
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
potency
≤1.0 ng/mL
mol wt
17.6 kDa
packaging
pkg of 5 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... FLT3(2322)
General description
Mouse and human Flt-3 ligand share ~72% homology and both demonstrate cross-species activity.
Biochem/physiol Actions
Flt-3/Flk-2 Ligand (FL, or Flt-3L) is a transmembrane glycoprotein that binds and activates the Flt-3 receptor. Expression of Flt-3 is primarily restricted among hematopoietic cells to the most primitive progenitor cells.
Physical form
Lyophilized, 0.2 μm sterile filtered, with with 0.5x PBS.
Analysis Note
The biological activity is measured by its ability to stimulate the proliferation of human AML5 cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
商品
Read article on hematopoietic cytokines and hematopoiesis
Lyman, S., et al. et al.
The Cytokine Handbook, 727-727 (1998)
R Namikawa et al.
Stem cells (Dayton, Ohio), 14(4), 388-395 (1996-07-01)
The biological activities of the ligand for the Flk2/Flt3 receptor tyrosine kinase (FL) on human hematopoietic cells are reviewed. In in vitro studies, FL shows relatively few effects by itself on the proliferation and differentiation of hematopoietic cells, but exhibits
H G Drexler et al.
Leukemia & lymphoma, 33(1-2), 83-91 (1999-04-08)
FLT3 ligand (FL) acting through its tyrosine kinase receptor FLT3 has pleiotropic and potent effects on hematopoietic cells. The well-described involvement of this ligand-receptor pair in physiological hematopoiesis raised the question whether FL and FLT3 also play a role in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F3422-5UG | 04061833613924 |