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F6889

法莫替丁

Name: 法莫替丁
Brand: SIGMA

histamine receptor antagonist

别名:

N′-（氨基磺酰基）-3-([2-（二氨基亚甲基氨基）-4-噻唑基]甲硫基)丙脒

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关于此项目

经验公式（希尔记法）:

C₈H₁₅N₇O₂S₃

化学文摘社编号:

76824-35-6

分子量:

337.45

UNSPSC Code:

12352200

PubChem Substance ID:

24278442

NACRES:

NA.77

MDL number:

MFCD00079297

Quality level:

100

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属性

产品名称

法莫替丁,

Quality Level

100

originator

Johnson & Johnson

SMILES string

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

InChI key

XUFQPHANEAPEMJ-UHFFFAOYSA-N

Gene Information

human ... HRH2(3274)

说明

Application

法莫替丁已用于测试其对HEK293膜中转染的人ether-a-go-go相关基因（hERG）结合的效应。它也被用于基于聚己内酯的药物递送研究。

Biochem/physiol Actions

法莫替丁对毒蕈碱和烟碱样受体无效。它竞争性地抑制胃酸的分泌，并引发粘膜损伤保护。

H₂组胺受体拮抗剂；抗溃疡剂。

Features and Benefits

该化合物由 Johnson & Johnson 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

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存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Slow-release of famotidine from tablets consisting of chitosan/sulfobutyl ether β-cyclodextrin composites.

Makoto Anraku et al.

International journal of pharmaceutics, 487(1-2), 142-147 (2015-04-18)

An intermolecular complex formed from a 1:1 weight ratio of chitosan (CS, molecular weight 30 kDa) and sulfobutyl ether β-cyclodextrin (SBE-β-CyD, degree of substitution 7) was less soluble than either of the original components. The release of famotidine from tablets

Polycaprolactone thin-film drug delivery systems: empirical and predictive models for device design

Schlesinger E, et al.

Materials Science and Engineering, C, 57, 232-239 (2015)

Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo.

Kenichi Yamamoto et al.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 30(12), 1958-1962 (2012-05-18)

Heterotopic ossification or calcification follows any type of musculoskeletal trauma and is known to occur after arthroplasties of hip, knee, shoulder, or elbow; fractures; joint dislocations; or tendon ruptures. Histamine receptor H2 (Hrh2) has been shown to be effective for

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全球贸易项目编号

货号	GTIN
F6889-1G	04061833619087
F6889-500MG	04061833619094
F6889-5G	04061832090856