F9427
盐酸非索非那定 盐酸盐
>98% (HPLC), H1 histamine receptor antagonist, powder
别名:
MDL 16455 盐酸盐, 羧酸非索芬那定 盐酸盐, 非索芬那定 盐酸盐
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关于此项目
经验公式（希尔记法）:
C32H39NO4 · HCl
化学文摘社编号:
分子量:
538.12
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
盐酸非索非那定 盐酸盐, >98% (HPLC)
Quality Level
assay
>98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: soluble ≥5 mg/mL
originator
Sanofi Aventis
storage temp.
−20°C
SMILES string
Cl[H].CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4
InChI
1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H
InChI key
RRJFVPUCXDGFJB-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269)
Application
盐酸非索非那定在NCI-H661细胞中用作非阳离子两亲性抗组胺剂在小鼠中用作组胺H1受体拮抗剂
Biochem/physiol Actions
非索非那定用于治疗过敏性鼻炎、慢性特发性荨麻疹等。它可以缓解烦躁症状，属于第二代抗组胺。与其他抗组胺药相比，非索非那定能更好地缓解鼻塞症状。它是特非那定的活性代谢产物，能够降低过敏原引起的症状。
非索非那定是一种非镇静性 H1 组胺受体拮抗剂。
Features and Benefits
该化合物是 ADME Tox research 的特色产品。 单击此处 可发现更多功能的 ADME Tox 产品。在 sigma.com/discover-bsm 了解更多关于其他研究领域的生物活性小分子。
该化合物由Sanofi Aventis开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Discover Bioactive Small Molecules for ADME/Tox
Jürgen Brüning et al.
The Journal of pharmacy and pharmacology, 67(6), 773-781 (2015-02-14)
This study describes the general method for the determination of the crystal structures of active pharmaceutical ingredients (API) from powder diffraction data and demonstrates its use to determine the hitherto unknown crystal structure of fexofenadine hydrochloride, a third-generation antihistamine drug.
Inhibitory effect of oblongifolin C on allergic inflammation through the suppression of mast cell activation
Lu Y, et al.
Molecular and Cellular Biochemistry, 406(1-2), 263-271 (2015)
A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis
Bachert C
Clinical Therapeutics, 31(5), 921-944 (2009)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F9427-10MG | 04061833621639 |
| F9427-50MG | 04061832082110 |