biological source
synthetic
Quality Level
form
powder
color
yellow
mp
256-256 °C
solubility
formic acid: 50 mg/mL
antibiotic activity spectrum
Gram-positive bacteria, parasites
mode of action
enzyme | inhibits
SMILES string
[O-][N+](=O)c1ccc(\C=N\N2CCOC2=O)o1
InChI
1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+
InChI key
PLHJDBGFXBMTGZ-WEVVVXLNSA-N
Application
呋喃唑酮是硝基呋喃衍生物,具有抗原虫和抗菌活性。呋喃唑酮与细菌 DNA 结合,从而导致单胺氧化酶逐渐受到抑制。用于治疗厌食和拮抗家禽对硫胺素的利用 。呋喃唑酮增加鸡心肌细胞中对毒胡萝卜素敏感的 Ca 2+-atp 酶 。
Biochem/physiol Actions
呋喃唑酮及其产生的自由基,可能与 DNA 结合并诱导交联。细菌 DNA 对本药特别敏感,从而导致细菌染色体的高水平突变(转换和颠换)。其作用机制使耐药生物体的发展最小化。呋喃唑酮是一种单胺氧化酶 (MAO) 抑制剂,用作 DNA 链间交联剂。
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signalword
Warning
hcodes
Hazard Classifications
Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
B H Ali et al.
Quarterly journal of experimental physiology (Cambridge, England), 67(3), 437-448 (1982-07-01)
Furazolidone (0.4% w/w in the feed, 10 days) reduced the feed intake and growth in 9 week old chickens, and increased the amount of 5-hydroxytryptamine (5-HT) in the brain. The drug also increased the stimulation of transketolase activity by thiamine
Am J Physiol Heart Circ Physiol. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes
D. Lax, R. Martinez-Zaguilan, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 267, H734-H741 (1994)
André Gustavo Tempone et al.
International journal of antimicrobial agents, 36(2), 159-163 (2010-06-18)
Drug delivery systems are promising pharmaceutical formulations used to improve the therapeutic index of drugs. In this study, we developed a liposomal formulation of furazolidone that targets Leishmania (Leishmania) chagasi amastigotes in a hamster model. Using laser scanning confocal microscopy
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F9505-10G | 04061833621721 |
| F9505-100G | 04061832991153 |
| F9505-25G | 04061833621776 |
