产品名称
菲律宾菌素复合体 来源于菲律宾链霉菌, ≥70% (UV)
biological source
Streptomyces sp. (Streptomyces filipinensis)
Quality Level
assay
≥70% (UV)
form
powder
solubility
methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow
antibiotic activity spectrum
fungi
mode of action
cell membrane | interferes
storage temp.
−20°C
InChI
1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
InChI key
IMQSIXYSKPIGPD-YQRUMEKGSA-N
General description
化学结构：大环内酯
Application
来自非律平链霉菌的非律平复合物已用作检测细胞中游离胆固醇的荧光探针。
Biochem/physiol Actions
菲律平是一种多烯大环内酯类抗生素和抗真菌药。抗真菌作用的机制尚不清楚，但可能是由于通过与膜固醇结合而改变了膜的通透性和相关功能。 非律平与膜固醇（如胆固醇）结合，抑制朊蛋白（PrP）的内吞作用，并使 PrP 从质膜释放。
菲律平是一种多烯大环内酯类抗生素和抗真菌药。抗真菌作用的机理尚不清楚，但可能是由于膜通透性改变所致。 非律平以形成膜孔的方向与含胆固醇的模型结晶相脂质双层结合，并与具有或没有胆固醇的液相双层结合。它既抑制蛋白（PrP）的内吞作用，又导致 PrP 从质膜释放。
Other Notes
非律平包含 8 个异构体成分，其中非律平 III 是主要成分。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F9765-25MG | 04061833621981 |
| F9765-50MG | 04061833621998 |