G1404
还原型谷胱甘肽乙酯
≥90% (TLC)
别名:
γ-GLU-半胱氨酸 - 甘氨酸 - OET, GSH-MEE
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关于此项目
经验公式（希尔记法）:
C12H21N3O6S
化学文摘社编号:
分子量:
335.38
UNSPSC Code:
12161504
PubChem Substance ID:
NACRES:
NA.26
MDL number:
产品名称
还原型谷胱甘肽乙酯, ≥90% (TLC)
Quality Level
assay
≥90% (TLC)
form
powder
color
white to off-white
storage temp.
−20°C
SMILES string
CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
InChI
1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1
InChI key
JKRODHBGNBKZLE-YUMQZZPRSA-N
Application
还原型谷胱甘肽乙酯已被用于：
- 提高小鼠成纤维细胞 L929 细胞内谷胱甘肽水平
- 作为 果翅目昆虫 (Sf) 9 细胞的培养基补充
- 以评价其对脊髓损伤后脂质过氧化作用
Biochem/physiol Actions
谷胱甘肽乙酯（还原型）可通过抑制Melan-A细胞中的酪氨酸酶活性来抑制黑色素合成。它的抗黑色素生成功能可用于治疗皮肤色素沉着过度性疾病。从胰腺分离胰岛时，添加谷胱甘肽乙酯(GEE)可减少活性氧物质生成和细胞凋亡。
还原型谷胱甘肽乙酯 (GSH—MEE) 是 GSH 的膜/脂质渗透性衍生物，可用于部分补充细胞内遭受半胱氨酸和/或 GSH 耗竭的 GSH 供应。GSH-MEE 被细胞内酯酶水解释放 GSH，从而增加细胞内 GSH 的浓度。 防止动物细胞中对乙酰氨基酚的毒性作用。保护人体淋巴细胞和皮肤成纤维细胞免受辐射造成的损伤。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Alison E M Vickers et al.
Toxicology and applied pharmacology, 244(3), 354-365 (2010-02-11)
A novel in vitro model to investigate time-dependent and concentration-dependent responses in blood cells and hemolytic events is studied for rat, dog, and human tissues. Whole blood is co-cultured with a precision-cut liver slice. Methimazole (MMI) was selected as a
Cytotoxic effects induced by oxidative stress in cultured mammalian cells and protection provided by Hsp27 expression
Arrigo A, et al.
Methods, 35(2), 126-138 (2005)
The glutathione derivative, GSH monoethyl ester, may effectively whiten skin but GSH does not
Chung B, et al.
International Journal of Molecular Sciences, 17(5), 629-629 (2016)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G1404-100MG | 04061833628102 |
| G1404-25MG | 04061833628119 |