主要文件

查看所有文档

G1918

Gö 6983

Name: Gö 6983
Brand: SIGMA

≥97%, PKC inhibitor, powder

别名:

3-[1- [3-（二甲氨基）丙基]-5-甲氧基-1H-吲哚-3-基] -4-（1H-吲哚-3-基）-1H-吡咯-2，5-二酮

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₆H₂₆N₄O₃

化学文摘社编号:

133053-19-7

分子量:

442.51

UNSPSC Code:

12352200

PubChem Substance ID:

24894916

NACRES:

NA.77

MDL number:

MFCD04040031

Assay:

≥97%

Form:

powder

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

Gö 6983, ≥97%

Quality Level

100

assay

≥97%

form

powder

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c2c1

InChI

1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)

InChI key

LLJJDLHGZUOMQP-UHFFFAOYSA-N

说明

Application

GO6983已作为蛋白激酶C（PKC）抑制剂，用以研究其对核输入的影响。它还用作Fc培养基中的补充剂，以在丝裂霉素C处理过的小鼠胚胎成纤维细胞（MEF）上培养小鼠胚胎干（mES）细胞。

Biochem/physiol Actions

蛋白激酶C（PKC）抑制剂选择性抑制几种 PKC 同工酶（PKCα和PKCβ的IC₅₀=7nM；PKCγ 为6 nM；PKCδ 为10 nM；PKCζ 为60nM），但不抑制PKCμ（IC₅₀=20 mM）。

Still not finding the right product?

Explore all of our products under Gö 6983

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

商品

Naive Pluripotent Stem Cell Culture in Serum-Free Media

Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

Shahbazi MN, et al.

Nature, 552(7684), 239-239 (2017)

Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.

Li-Chun Lisa Tsai et al.

The Journal of biological chemistry, 290(36), 21845-21856 (2015-07-19)

Atypical protein kinase C (aPKC) enzymes signal on protein scaffolds, yet how they are maintained in an active conformation on scaffolds is unclear. A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical PKCζ, zeta inhibitory peptide (ZIP)

Derivation of novel human ground state naive pluripotent stem cells.

Ohad Gafni et al.

Nature, 504(7479), 282-286 (2013-11-01)

Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2

查看所有相关文献

全球贸易项目编号

货号	GTIN
G1918-1MG	04061833628492
G1918-500UG	04061833628508