主要文件

查看所有文档

G3295

GW0742

Name: GW0742
Brand: SIGMA

≥98% (HPLC), selective PPARδ agonist, powder

别名:

[4-[[[2-[3-氟-4-(三氟甲基)苯基]-4-甲基-5-噻唑基]甲基]硫代]-2-甲基苯氧基]乙酸

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₁H₁₇F₄NO₃S₂

化学文摘社编号:

317318-84-6

分子量:

471.49

UNSPSC Code:

12352200

PubChem Substance ID:

24895123

NACRES:

NA.77

MDL number:

MFCD07369423

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

GW0742, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

mp

134.5-135.5 °C

solubility

DMSO: >5 mg/mL, H₂O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cc1cc(SCc2sc(nc2C)-c3ccc(c(F)c3)C(F)(F)F)ccc1OCC(O)=O

InChI

1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)

InChI key

HWVNEWGKWRGSRK-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465), PPARD(5467), PPARG(5468)

说明

Biochem/physiol Actions

GW0742是一种高度选择性的PPARδ激动剂。

GW0742是一种高度选择性的PPARδ激动剂。 EC₅₀= 1 nM ，对PPARα和PPARγ的EC50分别为1 μM和2 μM。

Features and Benefits

该化合物在受体分类和信号转导手册的核受体（PPAR）页面上有详细描述。如需浏览其他手册页面，请点击此处。

该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

Legal Information

根据GlaxoSmithKline的协议出售用于研究目的

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

PPAR-δ Agonist With Mesenchymal Stem Cells Induces Type II Collagen-Producing Chondrocytes in Human Arthritic Synovial Fluid.

Bruce E Heck et al.

Cell transplantation, 26(8), 1405-1417 (2017-09-14)

Osteoarthritis (OA) is an inflammatory joint disease characterized by degeneration of articular cartilage within synovial joints. An estimated 27 million Americans suffer from OA, and the population is expected to reach 67 million in the United States by 2030. Thus

High expression of Fatty Acid-Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells.

Koichiro Kawaguchi et al.

FEBS open bio, 6(3), 190-199 (2016-04-06)

Fatty acid-binding proteins (FABPs) are responsible for binding and storing hydrophobic ligands such as long-chain fatty acids, and for transporting these ligands to the appropriate compartments within the cell. The present study demonstrates that the FABP5 gene is upregulated in

Activation of PPARβ/δ prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries.

Daniel Morales-Cano et al.

Clinical science (London, England : 1979), 130(20), 1823-1836 (2016-07-15)

PPARβ/δ activation protects against endothelial dysfunction in diabetic models. Elevated glucose is known to impair cAMP-induced relaxation and Kv channel function in coronary arteries (CA). Herein, we aimed to analyse the possible protective effects of the PPARβ/δ agonist GW0742 on

查看所有相关文献

全球贸易项目编号

货号	GTIN
G3295-1MG	04061833629871
G3295-5MG	04061832954356