G4391
Gly-Arg-Gly-Asp-Ser
≥97% (HPLC)
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关于此项目
经验公式（希尔记法）:
C17H30N8O9
化学文摘社编号:
分子量:
490.47
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
Form:
powder
Assay:
≥97% (HPLC)
Quality Level
assay
≥97% (HPLC)
form
powder
composition
Peptide content, ≥60%
technique(s)
blocking: suitable, cell culture | mammalian: suitable
storage temp.
−20°C
SMILES string
NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O
InChI
1S/C17H30N8O9/c18-5-11(27)23-8(2-1-3-21-17(19)20)14(31)22-6-12(28)24-9(4-13(29)30)15(32)25-10(7-26)16(33)34/h8-10,26H,1-7,18H2,(H,22,31)(H,23,27)(H,24,28)(H,25,32)(H,29,30)(H,33,34)(H4,19,20,21)/t8-,9-,10-/m0/s1
InChI key
RGNVSYKVCGAEHK-GUBZILKMSA-N
Gene Information
human ... ITGB3(3690)
General description
Gly-Arg-Gly-Asp-Ser 肽序列与纤连蛋白的细胞结合区相同。Arg-Gly-Asp（RGD）区存在于各种蛋白质中，对促进细胞粘附活性很重要。
Application
Gly-Arg-Gly-Asp-Ser 已用于-
- 作为抗原，用在小鼠中确定整合素 α4 或 α5 是否阻碍照射后第 3 天胸腺细胞与胸腺上皮细胞的粘附
- 处理胶原蛋白 IV 包被的培养皿，研究整联蛋白 α1, αv、β1 和 β3 在 Sca-1+ 祖细胞分化为 SMC（平滑肌细胞）中的作用
- 作为脑膜炎奈瑟菌菌株预培养的封闭肽，用于进行研究这些细菌菌株与纤连蛋白之间的相互作用的封闭实验
- 预处理 AdCMV-GFP（巨细胞病毒-绿色荧光蛋白）感染的 EL-4 细胞，研究与细胞整联蛋白的相互作用对于腺病毒的转导是否是必需的
Biochem/physiol Actions
当与 B16-F10 黑色素瘤细胞共同注射时，Gly-Arg-Gly-Asp-Ser 抑制同系小鼠或缺乏血小板功能的小鼠的肿瘤转移。
整联蛋白功能拮抗剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
T Eberhard et al.
Infection and immunity, 66(4), 1791-1794 (1998-04-07)
Adhesion of Neisseria meningitidis strains to extracellular matrix (ECM) and purified matrix components was examined. Most strains bound to subendothelial ECM as well as to immobilized fibronectin and types I, III, and V collagen. Strains from healthy carriers adhered significantly
Annasara Hansson et al.
International journal of pharmaceutics, 439(1-2), 73-80 (2012-10-11)
Herein we describe the preparation of a nanoparticulate system formed from an RGD-functionalized chitosan derivative by complexation with chondroitin sulfate. These bioactive complexes were developed to promote wound healing by inducing adhesion and subsequently migration of skin cells. The particles
Qingzhong Xiao et al.
American journal of physiology. Cell physiology, 292(1), C342-C352 (2006-08-18)
Embryonic stem (ES) cells can differentiate into smooth muscle cells (SMCs) that can be used for tissue engineering and repair of damaged organs. However, little is known about the molecular mechanisms of differentiation in these cells. In the present study
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G4391-1MG | 04061826744840 |
| G4391-5MG | 04061833261811 |