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Merck
CN

G5419

Anti-GAD67 Antibody

clone K-87, purified antibody

别名:

抗-GAD 67

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关于此项目

MDL number:
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
K-87, monoclonal
Application:
IHC (p), WB
Citations:
21
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产品名称

单克隆抗-谷氨酸脱羧酶 67(GAD67) 小鼠抗, clone K-87, purified antibody

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

K-87, monoclonal

mol wt

antigen 67 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:20,000 (with antigen-retrieval step), western blot: 1:500-1:20,000 using mouse brain extract

isotype

IgG1κ

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

target post-translational modification

unmodified

Gene Information

human ... GAD1(2571)
mouse ... Gad1(14415)
rat ... Gad1(24379)

General description

谷氨酸脱羧酶67(GAD67)由基因谷氨酸脱羧酶1(GAD1)编码。GAD1基因位于人染色体2q31.1。GAD67位于树突和细胞体。

Immunogen

来自小鼠 GAD67 的合成肽(氨基酸 87-106)。
该肽与 GAD65 不具有同源性。

Application

小鼠抗谷氨酸脱羧酶67(GAD67)单克隆抗体已被用于:
  • 免疫组织荧光
  • 蛋白质印迹
  • 免疫组织化学

抗谷氨酸脱羧酶 67(GAD67)单克隆抗体适用于免疫印迹、免疫印迹(1:500-1:20,000 稀释,小鼠脑提取物)和免疫组化(1:500-1:20,000 稀释,小鼠脑切片)。

Biochem/physiol Actions

与 GAD67 特异性反应。不与 GAD65 发生交叉反应。
谷氨酸脱羧酶67(GAD67)涉及 γ-氨基丁酸 (GABA)的生产,氨基丁酸是中枢神经系统 (CNS)中的一种抑制性神经递质。GAD67缺乏会导致精神病、精神分裂和双向情感障碍。

Physical form

在含有 0.01% 叠氮化钠的磷酸盐缓冲盐水中的溶液。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。


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存储类别

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
低风险生物材料

此项目有



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Baohu Ji et al.
Human molecular genetics, 23(21), 5683-5705 (2014-06-09)
The t(1; 11) translocation appears to be the causal genetic lesion with 70% penetrance for schizophrenia, major depression and other psychiatric disorders in a Scottish family. Molecular studies identified the disruption of the disrupted-in-schizophrenia 1 (DISC1) gene by chromosome translocation
Baohu Ji et al.
PloS one, 8(6), e66327-e66327 (2013-07-05)
It has been well established that schizophrenia patients display impaired NMDA receptor (NMDAR) functions as well as exacerbation of symptoms in response to NMDAR antagonists. Abnormal NMDAR signaling presumably contributes to cognitive deficits which substantially contribute to functional disability in
Eric S Wohleb et al.
The Journal of clinical investigation, 126(7), 2482-2494 (2016-06-09)
Major depressive disorder (MDD) is a recurring psychiatric illness that causes substantial health and socioeconomic burdens. Clinical reports have revealed that scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces rapid antidepressant effects in individuals with MDD. Preclinical models suggest that



全球贸易项目编号

货号GTIN
G5419-100UG04061833634691