G6025
香叶基香叶基焦磷酸盐 铵盐
solution, ≥95% (TLC), ~1 mg/mL in methanol: NH4OH (7:3)
别名:
GGPP, 全反式-3,7,11,15-四甲基-2,6,10,14-十六烷基焦磷酸酯 铵盐
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关于此项目
经验公式（希尔记法）:
C20H36O7P2 · xNH3
化学文摘社编号:
分子量:
450.44 (free acid basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
Quality Level
assay
≥95% (TLC)
form
solution
packaging
vial of 200 μg
concentration
~1 mg/mL in methanol: NH4OH (7:3)
storage temp.
−20°C
SMILES string
C\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O
InChI
1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+
InChI key
OINNEUNVOZHBOX-QIRCYJPOSA-N
Application
香叶基香叶基焦磷酸盐已用于：
- 制备用于Rab GGTase测定的2.5X反应缓冲液
- 添加到培养物中，进一步驱动Hmg2降解
- 用作体外酶促测定鉴定异戊二烯基转移酶时的底物
- 逆转洛伐他汀作用，还用于检验GGPP在研究中的潜在作用，以评估在体外共培养血管生成模型中，洛伐他汀对黑素瘤细胞系的作用
Biochem/physiol Actions
香叶基香叶基焦磷酸酶（GGPP）是一种主要的酶，参与叶绿体的次级代谢。GGPP合酶在类萜生物合成中起关键作用。香叶基香叶基焦磷酸酶介导的蛋白质香叶基香叶基化参与心室的发育。它还可充当特定阶段的信号，调节妊娠中期心脏细胞结构的形成。
来自细胞内甲羟戊酸途径的类异戊二烯可用于几种低分子量G蛋白（包括Ras）的异戊烯化。 萜烯生物合成中间体。
Features and Benefits
该化合物是环核苷酸研究的推荐产品。点击此处，了解更多精选环核苷酸产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
51.8 °F - closed cup
flash_point_c
11 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G6025-5VL | 04061833638781 |
| G6025-1VL | 04061833638774 |