G6129
鸟苷-3′,5′-环一磷酸 钠盐
≥99% (HPLC), Cyclic nucleotide, powder
别名:
3′，5′-环GMP 单钠盐, 3′，5′-环磷酸鸟苷钠, cGMP, 环GMP, 鸟苷-3′,5′-环磷酸酯 单钠盐
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关于此项目
经验公式（希尔记法）:
C10H11N5NaO7P
化学文摘社编号:
分子量:
367.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
255-056-0
MDL number:
Beilstein/REAXYS Number:
6467425
产品名称
鸟苷-3′,5′-环一磷酸 钠盐, ≥99% (HPLC), powder
Quality Level
assay
≥99% (HPLC)
form
powder
color
white
solubility
H2O: 50 mg/mL
storage temp.
−20°C
SMILES string
[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)C(=O)N1
InChI
1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
InChI key
KMPIYXNEROUNOG-GWTDSMLYSA-M
Biochem/physiol Actions
作为重要的第二信使，cGMP是细胞外信号（例如一氧化氮和利尿钠肽）的主要细胞内介质。环状GMP可与三种类型的细胞内受体蛋白相互作用：cGMP依赖性蛋白激酶、cGMP调节的通道、以及cGMP调节的环核苷酸磷酸二酯酶。cGMP水平在体内升高的主要作用是刺激cGMP依赖性蛋白激酶（PKG）。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
G Colamartino et al.
The Journal of physiology, 440, 189-206 (1991-01-01)
1. Blockage and permeation of divalent cations through channels activated by guanosine 3',5'-cyclic monophosphate (cyclic GMP) were studied in membrane patches excised from retinal rods of the tiger salamander Ambystoma tigrinum by rapidly changing the ionic medium bathing the intracellular
Milton Packer et al.
Circulation, 131(1), 54-61 (2014-11-19)
Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs on the risk of clinical deterioration in surviving patients.
Sofia-Iris Bibli et al.
Cardiovascular research, 106(3), 432-442 (2015-04-15)
H2S is known to confer cardioprotection; however, the pathways mediating its effects in vivo remain incompletely understood. The purpose of the present study is to evaluate the contribution of cGMP-regulated pathways in the infarct-limiting effect of H2S in vivo. Anaesthetized
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G6129-25MG | 04061833638859 |
| G6129-500MG | 04061832898056 |
| G6129-100MG | 04061832898032 |
| G6129-1G | 04061826682722 |
| G6129-250MG | 04061832898049 |