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G6264

鸟苷

Name: 鸟苷
Brand: SIGMA

BioReagent, suitable for cell culture

别名:

9-(β-D-呋喃核糖基)鸟嘌呤, 鸟嘌呤-9-β-D-呋喃核糖苷

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₃N₅O₅

化学文摘社编号:

118-00-3

分子量:

283.24

PubChem Substance ID:

24895251

UNSPSC Code:

12352205

MDL number:

MFCD00010182

NACRES:

NA.75

EC Number:

204-227-8

Beilstein/REAXYS Number:

625911

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属性

biological source

synthetic

Quality Level

200

product line

BioReagent

assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

250 °C (dec.) (lit.)

solubility

0.05 M acetic acid: 1 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

[H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1

InChI key

NYHBQMYGNKIUIF-UUOKFMHZSA-N

说明

Application

鸟苷已用作：

作为基础培养基的核糖核苷组分，研究其对莫哈韦芽胞杆菌厌氧生长的影响
作为杜氏改良Eagle培养基（DMEM）的组分，用于培养小鼠来源的胚胎干细胞
作为核苷溶液的组分，用于培养鸡胚胎干细胞

Biochem/physiol Actions

鸟苷是一种在细胞代谢中起重要作用的嘌呤核苷。通过诱导增殖分化和抗凋亡作用，它在神经胶质细胞、海马神经元、嗜铬细胞瘤细胞中也表现出神经保护和神经营养作用。鸟苷可作为药物治疗多种神经疾病。它对败血症诱导的认知障碍、肝性脑病、脂多糖（LPS）诱导的炎症、缺血性损伤和叠氮化物诱导的氧化损伤有效果。鸟苷适用于细胞培养应用，作为一磷酸鸟苷（GMP）、二磷酸鸟苷（GDP）、三磷酸鸟苷（GTP）和环GMP（cGMP）的前体。

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存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

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Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

Nadine Gehrke et al.

Immunity, 39(3), 482-495 (2013-09-03)

Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base

Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates.

Jérémie Piton et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8858-8863 (2013-04-24)

The initiation of mRNA degradation often requires deprotection of its 5' end. In eukaryotes, the 5'-methylguanosine (cap) structure is principally removed by the Nudix family decapping enzyme Dcp2, yielding a 5'-monophosphorylated RNA that is a substrate for 5' exoribonucleases. In

Antitumor effects of a tetradentate amido-carboxylate ligands and corresponding square-planar palladium(II) complexes toward some cancer cells. Crystal structure, DFT modeling and ligand to DNA probe docking simulation.

Zoran D Matović et al.

Journal of inorganic biochemistry, 121, 134-144 (2013-02-05)

Novel square-planar palladium(II) complexes with O-N-N-O-type ligands H4mda (H4mda=malamido-N,N'-diacetic acid) and H4obp (H4obp=oxamido-N,N'-di-3-propionic acid) were prepared and characterized. The ligands coordinate to the palladium(II) ion via two pairs of deprotonated ligating atoms with square chelation. A four coordinate, square-planar geometry

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全球贸易项目编号

货号	GTIN
G6264-1G	04061833638996
G6264-25G	04061833639009
G6264-5G	04061833639016