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Merck
CN

G7127

鸟苷 5′-二磷酸 钠盐

≥96% (HPLC), synthetic (organic), powder

别名:

GDP

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关于此项目

经验公式(希尔记法):
C10H15N5O11P2
化学文摘社编号:
分子量:
443.20
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
Assay:
≥96% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
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产品名称

鸟苷 5′-二磷酸 钠盐, Type I, ≥96% (HPLC)

biological source

synthetic (organic)

Quality Level

type

Type I

assay

≥96% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O)c2N1

InChI

1S/C10H15N5O11P2.Na.H/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;

InChI key

PVMPTWQLNDHIEV-UHFFFAOYSA-N

Application

鸟苷 5′-二磷酸钠盐用于:
  • GTP-γ-35S官能化分析
  • Y1激动剂激活[35S]-鸟苷5′-O-(3-硫醇)三磷酸 (GTPγS)官能化结合
  • 重组蛋白表达和纯化

Biochem/physiol Actions

鸟苷5′-二磷酸 (GDP)是嘌呤鸟嘌呤的二磷酸核苷。GDP和GTP参与并且用于通过G-偶联蛋白受体(GCPR)和鸟嘌呤核苷酸交换因子(GEF)以及多种GTP酶作用的细胞信号研究。


存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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实验方案

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.


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Yanagisawa M, et al.
The Journal of Biological Chemistry, 283(26), 18344-18354 (2008)
N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT 1A agonist, as a putative mediator of quetiapine's antidepressant activity
Jensen N H, et al.
Neuropsychopharmacology, 33(10), 2303-2303 (2008)



全球贸易项目编号

货号GTIN
G7127-100MG04061833642375
G7127-10MG04061833642382
G7127-1G04061833642399
G7127-25MG04061833642405
G7127-500MG04061833642412