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G8134

加拉碘铵

Name: 加拉碘铵
Brand: SIGMA

≥98% (TLC), allosteric muscarinic receptor antagonist, powder

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关于此项目

经验公式（希尔记法）:

C₃₀H₆₀I₃N₃O₃

化学文摘社编号:

65-29-2

分子量:

891.53

NACRES:

NA.77

PubChem Substance ID:

24277837

UNSPSC Code:

12352116

EC Number:

200-605-1

MDL number:

MFCD00011832

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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属性

产品名称

加拉碘铵, ≥98% (TLC), powder, muscarinic receptor antagonist

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

235 °C (dec.) (lit.)

solubility

H₂O: 100 mg/mL, ethanol: soluble

storage temp.

2-8°C

SMILES string

[I-].[I-].[I-].CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC

InChI

1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3

InChI key

REEUVFCVXKWOFE-UHFFFAOYSA-K

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)

说明

Application

Gallamine triethiodide has been used:

as a relaxant for measuring spinal trigeminal nucleus recordings from single neurons.
as an antagonist in neuroblastoma cells as M2 receptor
to reduce eye movement during retinal surgery in rat

Biochem/physiol Actions

Gallamine triethiodide has anti-muscarinic effect. It is a competitive antagonist for the muscarinic receptor. Gallamine is regarded as neuromuscular blocking agent.

Muscle relaxant; allosteric muscarinic receptor antagonist with an order of potency of M₂ > M₁ = M₄ > M₃ = M₅. Ligand for the peripheral anionic binding site of acetylcholinesterase.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

吸湿

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

DISCOVER Bioactive Small Molecules for Neuroscience

Transcriptional response to muscarinic acetylcholine receptor stimulation: regulation of Egr-1 biosynthesis by ERK, Elk-1, MKP-1, and calcineurin in carbachol-stimulated human neuroblastoma cells

Rossler O, et al.

Archives of Biochemistry and Biophysics, 470(1), 93-102 (2008)

Exploration of the orthosteric/allosteric interface in human M1 muscarinic receptors by bitopic fluorescent ligands.

Sandrine B Daval et al.

Molecular pharmacology, 84(1), 71-85 (2013-04-23)

Bitopic binding properties apply to a variety of muscarinic compounds that span and simultaneously bind to both the orthosteric and allosteric receptor sites. We provide evidence that fluorescent pirenzepine derivatives, with the M1 antagonist fused to the boron-dipyrromethene [Bodipy (558/568)]

The inhibitory effect of gallamine on muscarinic receptors

Clark AL and Mitchelson F

British Journal of Pharmacology, 58(3), 323-331 (1976)

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全球贸易项目编号

货号	GTIN
G8134-25G	04061833643709
G8134-5G	04061833643716