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G9048

GANT61

≥98% (HPLC)

别名:

2，2＆＃8242;-[[二氢-2-（4-吡啶基）-1，3-（2H，4H）-嘧啶二基]双（亚甲基）]双[N，N-二甲基苯胺, NSC 136476

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关于此项目

经验公式（希尔记法）:
C27H35N5
化学文摘社编号:
500579-04-4
分子量:
429.60
MDL number:
MFCD14635408
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >2 mg/mL

storage temp.

2-8°C

SMILES string

N2(C(N(CCC2)Cc4c(cccc4)N(C)C)c3ccncc3)Cc1c(cccc1)N(C)C

InChI

1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3

InChI key

KVQOGDQTWWCZFX-UHFFFAOYSA-N

Biochem/physiol Actions

GANT61 是 Hh 信号通路 Gli 抑制剂。
GANT61 通过抑制 Gli1 的转录活性阻断 hedgehog 通路信号转导（IC50 =5 μM）。 在裸鼠中，GANT 61 可导致 22Rv1 人前列腺肿瘤细胞异种移植缩小。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
026M4716V
035M4728V
024M4711V
053M4724V
011M4625V

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Hong Zhang et al.
Journal of Cancer, 10(4), 990-1003 (2019-03-12)
Background: Accumulating evidence indicates that aberrant activation of the Hedgehog (Hh) signalling pathway by Glioma-associated oncogene (Gli) transcription factors is involved in the aggressive progression of cancers, including ovarian cancer. Whereas the molecular mechanism underlying this phenomenon remains unelucidated. Matrix
Deepika Neelakantan et al.
Nature communications, 8, 15773-15773 (2017-06-13)
Recent fate-mapping studies concluded that EMT is not required for metastasis of carcinomas. Here we challenge this conclusion by showing that these studies failed to account for possible crosstalk between EMT and non-EMT cells that promotes dissemination of non-EMT cells.
Liyao Xu et al.
International journal of oncology, 50(5), 1868-1878 (2017-04-11)
Multiple lines of evidence indicate that aberrant activation of Hedgehog (Hh) signaling plays an important role in tumorigenesis in human glioma. However, the underlying molecular mechanism and crucial downstream targets of glioma-associated oncogene (Gli), a primary transcriptional regulator of Hh signaling
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全球贸易项目编号

货号GTIN
G9048-25MG04061833218860
G9048-5MG04061833218877