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G9284

胍 盐酸盐 溶液

Colorless liquid, 7.8 - 8.3 M, pH- 4.5 - 5.5

别名:

亚氨基脲 盐酸盐, 盐酸胍, 胍盐酸盐

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关于此项目

经验公式（希尔记法）:
CH5N3 · HCl
化学文摘社编号:
50-01-1
分子量:
95.53
UNSPSC Code:
12352107
NACRES:
NA.55
PubChem Substance ID:
24895369
MDL number:
MFCD00013026
Beilstein/REAXYS Number:
3591990
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Quality Level

200

form

liquid

density

1.18 g/mL at 25 °C (lit.)

SMILES string

Cl.NC(N)=N

InChI

1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

InChI key

PJJJBBJSCAKJQF-UHFFFAOYSA-N

Gene Information

human ... KCNA1(3736), KCNA10(3744), KCNA2(3737), KCNA3(3738), KCNA4(3739), KCNA5(3741), KCNA6(3742), KCNA7(3743), KCNB1(3745), KCNB2(9312), KCNC1(3746), KCNC2(3747), KCNC3(3748), KCNC4(3749), KCND1(3750), KCND2(3751), KCND3(3752), KCNF1(3754), KCNG1(3755), KCNG2(26251), KCNG3(170850), KCNG4(93107), KCNH1(3756), KCNH2(3757), KCNH3(23416), KCNH4(23415), KCNH5(27133), KCNH6(81033), KCNH7(90134), KCNH8(131096), KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479), KCNS1(3787), KCNS2(3788), KCNS3(3790), KCNV1(27012), KCNV2(169522)

Application

盐酸胍溶液已用于：
  • 蛋白质变性
  • 对下丘脑、丘脑、前额叶皮层和脑干样本进行匀浆，提取总 β-淀粉样蛋白（Aβ）并进行 Aβ42 定量
  • 作为一种离液变性剂处理人类免疫缺陷病毒-1（HIV-1）样本，研究其对 HIV-1 敏感性的影响并测定蛋白质稳定性

Biochem/physiol Actions

盐酸胍（Gnd-HCl）是一种高效的离液剂（chaotropic agent），作为变性剂被广泛用于RNA分离、球蛋白变性和蛋白质复性研究。它是一种合适的样品缓冲剂，可用于亲和纯化的蛋白质复合物的快速有效的洗脱，以及之后的蛋白质消化步骤。GnHCl可用于提取富含细胞包基质（ECM）‐的组织，包括骨骼、软骨、韧带和肌腱中的蛋白质。Gnd-HCl不用于蛋白质组学实验，因为其在低摩尔浓度下会干扰胰蛋白酶活性并且在与十二烷基硫酸钠（SDS）结合时具有沉淀倾向。它适用于进行快速和单步亲和纯化质谱（AP-MS）实验。

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBD2396V
SLCG4857
SLCF6084
SLCD4424
SLBW4783

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Fackson Mwale et al.
Tissue engineering. Part A, 20(21-22), 2942-2949 (2014-05-03)
Link N is a naturally occurring peptide that can stimulate proteoglycan synthesis in intervertebral disc (IVD) cells. IVD repair can also potentially be enhanced by mesenchymal stem cell (MSC) supplementation to maximize extracellular matrix (ECM) production. In a previous study
Caitriona McKeever et al.
Journal of medicinal chemistry, 56(3), 700-711 (2013-01-11)
Considering the strong DNA minor groove binding observed for our previous series of diaromatic symmetric and asymmetric guanidinium and 2-aminoimidazolinium derivatives, we report now the synthesis of new aminoalkyl derivatives of diaromatic guanidines with potential as DNA minor groove binders
Masaatsu Adachi et al.
The Journal of organic chemistry, 78(4), 1699-1705 (2013-01-18)
We describe an improved synthesis of (-)-5,11-dideoxytetrodotoxin from an enone, which was used for synthesis of tetrodotoxin and its analogues in this laboratory. One of the major modifications was to establish a two-step guanidinylation of trichloroacetamide of a highly functionalized
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全球贸易项目编号

货号GTIN
G9284-500ML04061833650165
G9284-100ML04061833650158