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G9518

吉非罗齐

Name: 吉非罗齐
Brand: SIGMA

PPARα and PPARγ agonist, powder

别名:

2,2-二甲基-5-(2,5-二甲基苯氧基)戊酸, 2,2-二甲基-5-(2,5-二甲苯氧基)戊酸, 5-(2,5-二甲基苯氧基)-2,2-二甲基戊酸

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关于此项目

经验公式（希尔记法）:

C₁₅H₂₂O₃

化学文摘社编号:

25812-30-0

分子量:

250.33

NACRES:

NA.77

PubChem Substance ID:

24895377

UNSPSC Code:

12352200

EC Number:

247-280-2

MDL number:

MFCD00079335

Form:

powder

Quality level:

100

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属性

产品名称

吉非罗齐,

form

powder

Quality Level

100

SMILES string

Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1

InChI

1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

InChI key

HEMJJKBWTPKOJG-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465)

说明

General description

吉非罗齐是一种纤维酸衍生物和降血脂药。吉非罗齐可作为 PPARα（过氧化物酶体增殖物激活受体 α）的配体。

Application

吉非罗齐已被用于研究其对酵母细胞周期进程的影响。它已被用于研究贝特类药物对人细胞系中细胞增殖和基因表达的影响。

Biochem/physiol Actions

吉非罗齐选择性增加载脂蛋白 A-I 水平。在酵母细胞中，吉非罗齐的应用会延迟 DNA 复制的开始。它被用作血脂异常的治疗药物。

Features and Benefits

这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 + P330 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

胆固醇的运输

由于胆固醇是水不溶性分子，必须包装后才能在血浆中运输。包装胆固醇、胆固醇酯和甘油三酯以便运输的颗粒称为脂蛋白。

Discover Bioactive Small Molecules for Lipid Signaling Research

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Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

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Stimulating effect of normal-dosing of fibrates on cell proliferation: word of warning.

Katerina Cizkova et al.

Lipids in health and disease, 15(1), 164-164 (2016-09-24)

Fibrates are widely used hypolipidemic drugs, which serve as ligand of peroxisome proliferator-activated receptor α (PPARα). Recently, they have also been considered as potential anticancer agents. We studied effect of fibrates treatment on cell proliferation, expression of CYP2J2 and concomitant

Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine.

Scott A Hoose et al.

PloS one, 7(5), e36503-e36503 (2012-05-09)

Screening chemical libraries to identify compounds that affect overall cell proliferation is common. However, in most cases, it is not known whether the compounds tested alter the timing of particular cell cycle transitions. Here, we evaluated an FDA-approved drug library

Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action.

Gianluca Miglio et al.

British journal of pharmacology, 167(3), 641-653 (2012-05-19)

Peroxisome proliferator-activated receptor (PPAR) agonists exert anti-albuminuric effects. However, the nephroprotective effects of these drugs remain to be fully understood. We have investigated whether gemfibrozil, GW0742 and pioglitazone protect human podocytes against nutrient deprivation (ND)-induced cell death and the role

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全球贸易项目编号

货号	GTIN
G9518-5G	04061833650264
G9518-25G	04061833650257