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H0165

7-乙基-10-羟基喜树脂

Name: 7-乙基-10-羟基喜树脂
Brand: SIGMA

powder, ≥98% (HPLC)

别名:

SN-38

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₀N₂O₅

化学文摘社编号:

86639-52-3

分子量:

392.40

UNSPSC Code:

12352204

PubChem Substance ID:

329815105

NACRES:

NA.77

MDL number:

MFCD00871873

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属性

产品名称

7-乙基-10-羟基喜树脂, ≥98% (HPLC), powder

Quality Level

200

biological source

Artemisia annua

assay

≥98% (HPLC)

form

powder

solubility

DMSO: 1 mg/mL

storage temp.

−20°C

SMILES string

OC1=CC2=C(CC)C(C3)=C(N=C2C=C1)C(N3C4=O)=CC5=C4COC([C@]5(O)CC)=O

InChI

1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1

InChI key

FJHBVJOVLFPMQE-QFIPXVFZSA-N

说明

Application

7-Ethyl-10-hydroxycamptothecin has been used:

to inhibit enterovirus 71 (EV71) (H) infection
to screen the chemosensitivity of pancreatic adenocarcinoma cells
as a chemical to study its ability to reverse multidrug resistance (MDR), due to ATP binding cassette (ABC) transporters

Biochem/physiol Actions

Active metabolite of irinotecan. Inhibitor of topoisomerase I.

Active metabolite of irinotecan. Inhibitor of topoisomerase I.. Gene expression analysis of colon cancer cell lines treated with SN-38 showed differential effects: the majority of affected genes were down-regulated (including, most strongly, genes related to receptor and kinase activity, signal transduction, apoptosis, RNA processing, protein metabolism and transport, cell cycle and transcription. Some of the up-regulated genes were involved in apoptosis, transcription, development and differentiation.

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H360D,H372

pcodes

P201 - P202 - P260 - P264 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B - STOT RE 1

target_organs

Gastro-intestinal system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: prespecified subgroup analyses from the VELOUR trial.

Josep Tabernero et al.

European journal of cancer (Oxford, England : 1990), 50(2), 320-331 (2013-10-22)

The antiangiogenic agent aflibercept (ziv-aflibercept in the United States) in combination with 5-fluorouracil, leucovorin and irinotecan (FOLFIRI) significantly improved survival in a phase III study of patients with metastatic colorectal cancer (mCRC) previously treated with an oxaliplatin-based regimen. In the

Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG 4007 trial.

Shuichi Hironaka et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(35), 4438-4444 (2013-11-06)

This phase III study compared treatment with weekly paclitaxel and biweekly irinotecan in patients with advanced gastric cancer refractory to treatment with fluoropyrimidine plus platinum. Patients were randomly assigned to receive either paclitaxel (80 mg/m(2) on days 1, 8, and

The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation.

J Hu et al.

Clinical and experimental immunology, 172(3), 490-499 (2013-04-23)

Recent studies indicate that chemotherapeutic agents may increase the anti-tumoral immune response. Based on the pivotal role of dendritic cells (DCs) in host tumour-specific immune responses, we investigated the effect of commonly used chemotherapeutic drugs dexamethasone, doxorubicin, cisplatin and irinotecan

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货号	GTIN
H0165-10MG	04061833662748
H0165-50MG	04061833662779