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H108

半胆碱-3

Name: 半胆碱-3
Brand: SIGMA

≥95% (HPLC), acetylcholine synthesis inhibitor, solid

别名:

2,2′-（4,4′-联苯）双（2-羟基-4,4-二甲基吗啉溴）

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关于此项目

经验公式（希尔记法）:

C₂₄H₃₄Br₂N₂O₄

化学文摘社编号:

312-45-8

分子量:

574.35

NACRES:

NA.77

PubChem Substance ID:

24278169

UNSPSC Code:

12352200

EC Number:

206-227-3

MDL number:

MFCD00011978

Beilstein/REAXYS Number:

5704458

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

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属性

产品名称

半胆碱-3, solid, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

solid

color

white

solubility

ethanol: 1.3 mg/mL, H₂O: 10 mg/mL

SMILES string

[Br-].[Br-].C[N+]1(C)CCOC(O)(C1)c2ccc(cc2)-c3ccc(cc3)C4(O)C[N+](C)(C)CCO4

InChI

1S/C24H34N2O4.2BrH/c1-25(2)13-15-29-23(27,17-25)21-9-5-19(6-10-21)20-7-11-22(12-8-20)24(28)18-26(3,4)14-16-30-24;;/h5-12,27-28H,13-18H2,1-4H3;2*1H/q+2;;/p-2

InChI key

OPYKHUMNFAMIBL-UHFFFAOYSA-L

说明

Application

半胆碱基-3已被用于制备Krebs-HC-3缓冲液，研究其对分化的人神经母细胞瘤（SK-N-SH）细胞中胆碱摄取和胆碱乙酰转移酶活性的影响。

Biochem/physiol Actions

半胆碱基-3在阻止神经元胆碱摄取方面起一定的作用，从而可以抑制大脑中乙酰胆碱的合成。

Features and Benefits

该化合物收录于受体分类和信号转导手册的《乙酰胆碱合成与代谢》页面。想要浏览手册的其他页面，请单击此处。

pictograms

GHS06

signalword

Danger

hcodes

H301 + H311 + H331,H315,H319,H335

pcodes

P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Phosphatidylcholine metabolism and choline kinase in human osteoblasts.

Zhuo Li et al.

Biochimica et biophysica acta, 1841(6), 859-867 (2014-03-04)

There is a paucity of information about phosphatidylcholine (PC) biosynthesis in bone formation. Thus, we characterized PC metabolism in both primary human osteoblasts (HOB) and human osteosarcoma MG-63 cells. Our results show that the CDP-choline pathway is the only de

Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging.

Edward D Levin et al.

Behavioural brain research, 208(2), 319-327 (2009-12-18)

Developmental exposure of rats to the organophosphate (OP) pesticides leads to altered neurobehavioral function in juvenile and young adult stages. The current study was conducted to determine whether effects of neonatal parathion exposure on cognitive performance persist in older adult

Characterization of choline uptake in prostate cancer cells following bicalutamide and docetaxel treatment.

Sebastian A Müller et al.

European journal of nuclear medicine and molecular imaging, 36(9), 1434-1442 (2009-04-09)

Choline derivatives labelled with positron emitters are successfully used for PET imaging of prostate cancer patients. Since little is known about uptake mechanisms, the aim of this study was to characterize choline uptake in prostate cancer cells, also following anti-androgen

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全球贸易项目编号

货号	GTIN
H108-100MG	04061833663868
H108-500MG	04061833663875