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H127

p-Fluorohexahydro-sila-difenidol hydrochloride

Name: <I>p</I>-Fluorohexahydro-sila-difenidol hydrochloride
Brand: SIGMA

powder, ≥98% (HPLC)

别名:

Cyclohexyl-(4-fluorophenyl)-(3-N-piperidinopropyl)silanol hydrochloride, P-F-HHSiD hydrochloride

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关于此项目

经验公式（希尔记法）:

C₂₀H₃₂FNOSi · HCl

化学文摘社编号:

116679-83-5

分子量:

386.02

NACRES:

NA.77

PubChem Substance ID:

24277841

UNSPSC Code:

12352200

MDL number:

MFCD00078582

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: slightly soluble 1.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL, ethanol: soluble

SMILES string

Cl[H].O[Si](CCCN1CCCCC1)(C2CCCCC2)c3ccc(F)cc3

InChI

1S/C20H32FNOSi.ClH/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22;/h10-13,19,23H,1-9,14-17H2;1H

InChI key

JMTYYLMGSBSPPK-UHFFFAOYSA-N

Gene Information

human ... CHRM3(1131)

说明

Application

p-Fluorohexahydro-sila-difenidol hydrochloride (pFHHSid) has been used:

as the M3/muscarinic acetylcholine receptor antagonist to study its involvement in carbachol induced Egr-1 biosynthesis using human neuroblastoma cells
as M3 receptor antagonist to test its involvement on N,N-diethyl-m-toluamide (DEET)-induced angiogenesis in human umbilical venous endothelial cells (HUVEC)
in a study to examine the role of aclidinium on human fibroblast to myofibroblast

Biochem/physiol Actions

High affinity M₃ muscarinic acetylcholine receptor antagonist.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation.

Kunrong Cheng et al.

American journal of physiology. Gastrointestinal and liver physiology, 295(3), G591-G597 (2008-07-26)

Most colon cancers overexpress M3 muscarinic receptors (M3R), and post-M3R signaling stimulates human colon cancer cell proliferation. Acetylcholine (ACh), a muscarinic receptor ligand traditionally regarded as a neurotransmitter, may be produced by nonneuronal cells. We hypothesized that ACh release by

Midbrain muscarinic receptor mechanisms underlying regulation of mesoaccumbens and nigrostriatal dopaminergic transmission in the rat.

Anthony D Miller et al.

The European journal of neuroscience, 21(7), 1837-1846 (2005-05-05)

Laterodorsal (LDT) and pedunculopontine (PPT) tegmental nuclei in the mesopontine project cholinergic inputs to the midbrain ventral tegmental area (VTA) and substantia nigra pars compacta (SNc), respectively, to directly and indirectly influence the activity of dopamine neuronal cells via actions

Muscarinic M1 and M3 receptors in rat striatum: a binding study.

M T de la Vega et al.

Archives of medical research, 28(4), 493-497 (1997-01-01)

In this study, the authors set out to determine the presence of M3 muscarinic receptors in rat striatum by examining the binding of [3H]N-methylscopolamine ([3H]NMS) to striatal membranes and its displacement by antagonists with different affinity for M1 and M3

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全球贸易项目编号

货号	GTIN
H127-50MG	04061832082332
H127-10MG	04061833664841