H2519
肝素酶 I 来源于肝素黄杆菌
Lyophilized powder stabilized with approx. 25% bovine serum albumin, ≥200 units/mg protein (enzyme + BSA)
别名:
肝素裂解酶I, 肝素酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
≥200 units/mg protein (enzyme + BSA)
conjugate
conjugate (Glucosaminoglycan)
Quality Level
form
lyophilized solid
specific activity
≥200 units/mg protein (enzyme + BSA)
mol wt
42.8 kDa
application(s)
diagnostic assay manufacturing
storage temp.
−20°C
Application
来自肝素黄杆菌（Flavobacterium heparinum）的肝素酶I已被用于：
- 消化血浆样品
- 研究培养基、洗涤和超声处理对肺炎衣原体(Chlamydia pneumonia)感染性的影响
- 酶法去除人横纹肌肉瘤细胞表面的硫酸乙酰肝素
Biochem/physiol Actions
来自肝素黄杆菌（Flavobacterium heparinum）的肝素酶I通过裂解肝素AT III结合位点处的α-糖苷键而发挥作用。这就产生了小的寡糖碎片。肝素酶 I 可以中和蛋白质的抗凝作用。肝素酶I的半衰期为15-18分钟。
Other Notes
在25 °C、pH 7.5条件下，一个单位（Sigma单位）每小时可形成0.1 μ摩尔不饱和糖醛酸。一个国际单位（I.U.）相当于大约600个Sigma单位。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
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Gabriel E Bertolesi et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 240(12), 2657-2672 (2011-11-11)
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Udayanath Aich et al.
Analytical chemistry, 83(20), 7815-7822 (2011-08-26)
Heparin and the low molecular weight heparins are extensively used as medicinal products to prevent and treat the formation of venous and arterial thrombi. In early 2008, administration of some heparin lots was associated with the advent of severe adverse
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H2519-50UN | 04061833792308 |
| H2519-100UN | 04061833792285 |
| H2519-250UN | 04061833792292 |