H4881
氢化可的松琥珀酸酯 钠盐
synthetic (organic), ≥90% (HPLC), Glucocorticoid receptor agonist, powder
别名:
11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate 钠盐, 氢化可的松 21-半琥珀酸酯 钠盐
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关于此项目
经验公式（希尔记法）:
C25H33NaO8
化学文摘社编号:
分子量:
484.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
204-725-5
MDL number:
产品名称
氢化可的松琥珀酸酯 钠盐, ≥90% (HPLC)
biological source
synthetic (organic)
Quality Level
assay
≥90% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to faintly yellow
shipped in
ambient
storage temp.
−20°C
SMILES string
O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(COC(CCC([O-])=O)=O)=O)=C1.[Na+]
InChI
1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
InChI key
HHZQLQREDATOBM-CODXZCKSSA-M
Gene Information
human ... NR3C1(2908)
Application
Hydrocortisone 21-hemisuccinate sodium salt has been used:
- as a component of the maturation medium for hepatic differentiation
- in the corticosterone (CORT) treatment to study its effect on astrocyte-like neural stem cell proliferation in the area postrema of the adult mouse brain
- in cortisol incubation experiments to study the effect of cortisol on the expression and function of sodium-chloride cotransporter (NCC) in zebrafish embryos
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signalword
Warning
hcodes
pcodes
Hazard Classifications
Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Influence Of Cortisol On The Attachment And Metamorphosis Of Larval Utterbackia Imbecillis On Bluegill Sunfish (Lepomis Macrochirus).
Dubansky, B., et al.
The Biochemical Journal, 220, 97-106 (2011)
Yuri Nambu et al.
Neuroscience letters, 748, 135732-135732 (2021-02-17)
The discovery of neural stem cells (NSCs) in the adult mammalian brain has provided insights into an extra level of brain plasticity. The proliferation and differentiation of NSCs is modulated by various physiological, pathological, and pharmacological stimuli. NSCs were recently
Eleonora Nucera et al.
European journal of endocrinology, 164(1), 139-140 (2010-10-22)
We present the case of a woman with 'empty sella syndrome' who experienced generalized urticaria after the administration of sodium succinate hydrocortisone in two episodes. The patient underwent an allergological evaluation (prick, intradermal, and patch tests) with hydrocortisone sodium succinate
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H4881-100MG | 04061832850412 |
| H4881-1G | 04061826236642 |