Quality Level
assay
≥95%
form
powder
functional group
hydroxyl
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)C
InChI
1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3
InChI key
OYXZMSRRJOYLLO-UHFFFAOYSA-N
Application
7β-羟胆固醇在人内皮细胞中可用于研究氧固醇诱导的凋亡。
Biochem/physiol Actions
7β-羟基胆固醇是一种氧固醇，即胆固醇氧化的酶促或非酶促产物。氧固醇具有细胞毒性，在单核细胞、平滑肌细胞和内皮细胞中可诱导死亡。 氧固醇诱导的细胞凋亡机制可能涉及胱氨酸蛋白酶或DNA片段化。7β-羟基胆固醇的水平升高与包括动脉粥样硬化在内的心血管疾病风险提高相关。
Preparation Note
无论是否加热，β-羟基胆固醇在乙醇中都会生成澄清、无色至淡黄色的溶液。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ludovic Clarion et al.
Biochemical pharmacology, 83(1), 37-46 (2011-10-11)
7β-Hydroxycholesterol cytotoxicity has been shown in vivo and in vitro to be dependent on the accumulation of its esters. We show in our study, using a detergent-free raft preparation and LC/MS lipid content analysis, that membrane microdomains isolated from 7β-hydroxycholesterol-treated
Raymond C S Seet et al.
Free radical research, 47(4), 283-290 (2013-01-25)
The purpose of this study was to evaluate the use of Framingham risk scores (FRRs) to identify high-risk individuals with biochemical evidence of increased oxidative damage, who may benefit from antioxidant therapies. A bimodal change in plasma F2-isoprostane levels was
G Lizard et al.
FEBS letters, 419(2-3), 276-280 (1998-01-15)
The oxysterols, 7beta-hydroxycholesterol and 7-ketocholesterol, are involved in the cytotoxicity of oxidized LDL. To elucidate their molecular mechanisms, the human promonocytic leukemia cells U937 and U4 were used. U4 cells overexpressing Bcl-2 were obtained by transfection of U937 cells. 7Beta-hydroxycholesterol
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H6891-1MG | 04061833802427 |
| H6891-10MG | 04061833076538 |
| H6891-5MG | 04061833802533 |