Anti-Huntingtin Disease (HD/HTT) Antibody

Anti-Huntingtin (N-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human huntingtin, conjugated to KLH.

Anti-Huntingtin (N-terminal) antibody has been used:

• in magnetic bead-assisted immunopurification
• in western blotting
• in immunofluorescent staining
• in immunoblotting

Huntingtin (Htt) is essential for embryonic development and neurogenesis. Htt associates with various cell organelles like the nucleus, endoplasmic reticulum and Golgi complex. It is also found in neurites and synapses where it associates with vesicular structures and microtubules, suggesting that it may play a role in intracellular vesicular trafficking, calcium homeostasis, neuronal survival, morphogenesis and transcriptional regulation. Aberrant expansion of glutamine repeats (polyQ) in the N-terminal region of huntingtin (htt) causes Huntington′s disease (HD) which is an autosomal dominant neurodegenerative disorder.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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