H9384
22 (R)-羟基胆固醇
≥98%
别名:
22α-羟基胆固醇, 5-胆甾烯-3β,22(R)-二醇, 5-胆甾烯3β,22[R]-二醇
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关于此项目
经验公式（希尔记法）:
C27H46O2
化学文摘社编号:
分子量:
402.65
UNSPSC Code:
12352211
eCl@ss:
39023139
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Quality Level
assay
≥98%
form
powder
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])[C@H](C)[C@H](O)CCC(C)C
InChI
1S/C27H46O2/c1-17(2)6-11-25(29)18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20-,21-,22+,23-,24-,25+,26-,27+/m0/s1
InChI key
RZPAXNJLEKLXNO-GFKLAVDKSA-N
Application
使用22（R）-羟基胆固醇处理牛主动脉内皮细胞以研究其对自由基产生的影响 以及用于与脂肪酸代谢有关的研究。
Biochem/physiol Actions
22（R）-羟基胆固醇是从胆固醇合成孕烯醇酮途径中的一种中间体。据报道它具有神经保护特性并可保护神经元免受β-淀粉样蛋白诱导的细胞死亡。 22(R)-羟基胆固醇可作为肝X受体的配体，该受体可充当甾醇浓度的传感器并调节脂肪酸代谢。
Preparation Note
22（R）-羟基胆固醇在氯仿中可产生澄清无色的溶液。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A Chawla et al.
Science (New York, N.Y.), 294(5548), 1866-1870 (2001-12-01)
Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only nutritionally important but serve as precursors for ligands that bind to receptors in the nucleus. To become biologically active, these lipids must first be absorbed
Zhi-Xing Yao et al.
Journal of neurochemistry, 83(5), 1110-1119 (2002-11-20)
22R-hydroxycholesterol, a steroid intermediate in the pathway of pregnenolone formation from cholesterol, was found at lower levels in Alzheimer's disease (AD) hippocampus and frontal cortex tissue specimens compared to age-matched controls. beta-Amyloid (Abeta) peptide has been shown to be neurotoxic
Jingsong Ou et al.
Circulation research, 97(11), 1190-1197 (2005-10-15)
Previously we showed L-4F, a novel apolipoprotein A-I (apoA-I) mimetic, improved vasodilation in 2 dissimilar models of vascular disease: hypercholesterolemic LDL receptor-null (Ldlr(-/-)) mice and transgenic sickle cell disease mice. Here we determine the mechanisms by which D-4F improves vasodilation
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H9384-1MG | 04061833812440 |
| H9384-5MG | 04061833812457 |