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HPA001906

Anti-ATRX Antibody

Name: Anti-ATRX Antibody
Brand: SIGMA

Prestige Antibodies^® Powered by Atlas Antibodies, rabbit polyclonal

别名:

ATP依赖性解旋酶ATRX抗体, ATRX抗体 - 兔抗ATRX抗体, Atrx抗体, X连锁解旋酶II抗体, Znf-HX抗体, JMS, RAD54, XH2, XNP

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关于此项目

UNSPSC Code:

12352203

Human Protein Atlas Number:

HPA001906

NACRES:

NA.41

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IHC

Citations:

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属性

产品名称

抗ATRX 兔抗, Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies^® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
RNAi knockdown
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL, immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:500-1:1000

UniProt accession no.

P46100

application(s)

research pathology

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATRX(546)

说明

Immunogen

对应于α地中海贫血/智力低下综合征X连锁的重组蛋白。

序列
AAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRR

Application

由Atlas Antibodies提供技术支持的所有Prestige Antibodies抗体均由人类蛋白质图集(HPA)项目开发和验证，因此受到业内最广泛的表征支持。

人类蛋白质图集项目可以分为三大部分：人体组织图谱、癌症图谱和人类细胞图谱。在组织和癌症图谱项目支持下产生的抗体已通过对数百种正常和疾病组织的免疫组织化学分析得到了验证，并且通过近期人类细胞图谱项目的努力，许多抗体已经过免疫荧光分析的表征，从而绘制人类蛋白质组图谱，不仅是在组织水平上，现在已经达到亚细胞水平。在人类蛋白质图集项目网站上单击图像库链接，可以查看这些图像和庞大的数据集。我们提供Prestige Antibodies^®抗体的实验方案和其他有用信息。兔抗-ATRX抗体可用于免疫组化实验。

Features and Benefits

Prestige Antibodies^®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies^®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige Antibody都存在有对应的Prestige抗原对照，并可在链接区域内找到。

每个Prestige Antibody均按照以下方法进行测试：

44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
364个人类重组蛋白片段的蛋白阵列。

Physical form

溶于磷酸盐缓冲盐水，pH 7.2，含有40%甘油和0.02%叠氮化钠

Other Notes

相应抗原APREST74299

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

10 - Combustible liquids

wgk

WGK 1

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品

低风险生物材料

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商品

抗体简介：抗原、表位和抗体

抗体可与特定的抗原结合，产生独特的抗体-抗原复合物。本文讨论这一连接键的性质，以及其作为分子标签的研究应用。

抗体基础知识

探索抗体处理基础知识，包括有关结构、类别和正常免疫球蛋白系列的技术信息。

An Introduction to Antibodies: Antigens, Epitopes and Antibodies

Antibodies combine with specific antigens to generate an exclusive antibody-antigen complex. Learn about the nature of this bond and its use as a molecular tag for research.

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Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas.

Doreen N Nguyen et al.

Brain pathology (Zurich, Switzerland), 23(3), 237-243 (2012-08-30)

Recent studies suggest that the telomere maintenance mechanism known as alternative lengthening of telomeres (ALT) is relatively more common in specific glioma subsets and strongly associated with ATRX mutations. We retrospectively examined 116 high-grade astrocytomas (32 pediatric glioblastomas, 65 adult

CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas.

Gerald F Reis et al.

Journal of neuropathology and experimental neurology, 74(5), 442-452 (2015-04-09)

Lower-grade (World Health Organization Grades II and III) gliomas vary widely in clinical behavior and are classified as astrocytic, oligodendroglial, or mixed. Anaplasia depends greatly on mitotic activity, with CDKN2A loss considered as the most common mechanism for cell cycle

ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment.

David Valle-García et al.

Epigenetics, 11(6), 398-414 (2016-04-01)

ATRX is a SWI/SNF chromatin remodeler proposed to govern genomic stability through the regulation of repetitive sequences, such as rDNA, retrotransposons, and pericentromeric and telomeric repeats. However, few direct ATRX target genes have been identified and high-throughput genomic approaches are

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全球贸易项目编号

货号	GTIN
HPA001906-100UL	04061833814352
HPA001906-25UL	04061842780419