biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL, immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:1000-1:2500
immunogen sequence
HGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CASP3(836)
General description
CASP3(胱天蛋白酶3),属于异构调节蛋白,是半胱氨酸-天冬氨酸蛋白酶(胱天蛋白酶)家族成员,参与炎症和哺乳动物细胞凋亡。含小分子和肽结合位点。
Immunogen
胱天蛋白酶-3前体重组蛋白抗原表位标签(PrEST)
Application
兔抗胱天蛋白酶3(CASP3)抗体,属Prestige Antibody抗体,由人类蛋白质图谱(HPA)计划开发验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接,可以在人类蛋白质图谱(HPA)站点上查看这些图像。还采用免疫荧光和蛋白质印迹法对抗体进行检测。想要查看有关Prestige 抗体和HPA的方案和其他实用信息,请访问 sigma.com/prestige。
Biochem/physiol Actions
CASP3(胱天蛋白酶3)可影响经细胞毒性治疗的黑色素瘤生长。它在细胞凋亡的执行阶段对周围细胞的增殖有重要作用。胱天蛋白酶通常以无活性酶原形式合成并定位。随后经蛋白水解级联反应加工激活。激活后,形成两个独立的亚基,进一步二聚化形成活性酶。胱天蛋白酶3可由活性氧(ROS)积累、线粒体功能障碍和腺苷三磷酸(ATP)水平降低而触发激活。CASP3基因的改变与阿尔茨海默病的神经元死亡有关。
Features and Benefits
Prestige Antibodies®是经过高度表征和广泛验证的抗体,同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品,可在链接部分找到。
每种Prestige 抗体的检测方法如下:
每种Prestige 抗体的检测方法如下:
- 44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
- 364个人重组蛋白片段的蛋白阵列。
Physical form
磷酸盐缓冲盐水溶液,pH 7.2,含有40%甘油和0.02%叠氮化钠
Other Notes
对应抗原APREST86566
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
常规特殊物品
此项目有
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| HPA002643-25UL | 04061842781546 |
| HPA002643-100UL | 04061833814468 |